| Amit Agrawal, MD | 12/01/07-08/30/12 | NIH/NCI |
| Christopher Weghorst, PhD | R01CA127368 | |
| Food-Based Modulation of Biomarkers in Human Tissues at High Risk for Oral Cancer | ||
| Lauren Bakaletz, PhD | 09/20/02 - 08/31/13 | NIH RO1 |
| Subinoy Das, MD | R01DC05847 | |
| Antimicrobial Peptides & Innate Immunity in Otits Media | ||
| The goal of this project is investigate the role of innate immunity in otitis media and identify methods to augment these defense mechanisms in order to develop a novel approach for the treatment and/or prevention of otitis media. | ||
| Lauren Bakaletz, PhD | 01/01/04 - 12/31/10 | NIH RO1 |
| Joan Durbin, MD, PhD | R01DC006468 | |
| RSV Upper Airway Infection & Otitis Media | ||
| The goal of this project is to explore the mechanism of protection as well as the ability of a recently developed RSV vaccine to inhibit bacterial otitis media following viral and bacterial co-infection. | ||
| Lauren Bakaletz, PhD | 09/30/99 - 08/31/10 | NIH RO1 |
| Determinants of H. influenzae Virulence in Otitis Media | R01DC003915 | |
| The goal of this project is to continue to enhance our understanding of nontypeable Haemophilus influenzae pathogenesis in otitis media as well as continue to identify and characterize putative virulence determinants and assess their potential as vaccine or therapeutic targets. | ||
| Lauren Bakaletz, PhD | 4/01/06-3/31/10 | NIH/NIDCD |
| Anthony A. Campagnari, PhD | R01DC007153 | |
| M. catarrhalis pili: Role in colonization and infection | ||
| Lauren Bakaletz, PhD | 7/17/09-10/15/11 | NIH/NIDCD |
| Determinants of H. influenzae Virulence in Otitis Media Supplement | ||
| Subinoy Das, MD | 02/01/09-01/31/11 | NIH |
| KL2RR025754 | ||
| Improving Patient Care via Proteomics Based, Microbe-Specific Detection of Chronic Rhinosinusitis | ||
| The goals of this project are to 1) identify patients with chronic rhinosinusitis (CRS), specifically due to the presence of NTHI biofilms, utilizing a high throughput proteomics-based assay, and 2) test a priori assay that will predict the development of CRS in an in vivo chinchilla model. Results from this project may lead to the development of biomarkers to be used as clinical diagnostic tools to diagnose CRS at very early stages of disease progression, and aid in the development non-surgical therapies for CRS. | ||
| Abraham Jacob, MD | 08/01/09-08/01/14 | NIH/NCI |
| 1K08DC009644-01A1 | ||
| Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma | ||
| Vestibular schwannomas (VS), brain tumors arising from the balance nerve, are one of the few deadly diseases of the ear, and patients with VS are currently treated with high risk modalities such as surgery and/or radiation therapy because no effective drugs are available. Our proposal seeks to study OSU-03012, a new drug that may revolutionize the treatment of VS. We plan to better understand how OSU-03012 inhibits VS tumor growth and profile its safety/efficacy parameters in order to transition this drug into human clinical trials. | ||
| Bomjun Kwon, PhD | 12/01/08 - 11/30/11 | NIH/NIDCR |
| Perceptual effects of mixed channel configurations in cochlear implants | R03DC009061 | |
| Susan Nittrouer, PhD | 09/01/03-02/28/10 | NIH/NIDCD |
| Early Development of Children with Hearing Loss | R01DC006237 | |
| The goal of this project is to investigate outcomes for children with hearing loss as a function of age of identification, whether signs were used in early intervention or not, and type of prosthesis. | ||
| Susan Nittrouer, PhD | 12/01/88-11/30/10 | NIH/NIDCD |
| Ontogeny of Segmental Speech Organization | R01DC000633 | |
| The goal of this project is to investigate how children acquire access to segmental structure in the speech signal which largely lacks any explicit acoustic structure. | ||
| Quintin Pan, PhD | 07/01/08-05/31/13 | NIH RO1 |
| Role of PKCepsilon in Oral Cancer | R01CA135069 | |
| The goal of this project is to study the biological role of PKCepsilon in the development of metastasis , a recalcitrant challenge in oral squamous cell carcinoma. | ||
| Hua Hua Tong, MD | 07/01/08-06/30/12 | NIH RO1 |
| Complement in S. Pneumoniae Otitis Media | R01DC009235 | |
| The goal of this project is to explore the critical role of complement in the middle ear in host innate immunity against Streptococcus pneumoniae, a primary pathogen of otitis media. | ||
| Hua Hua Tong, MD | 09/24/09-08/31/11 | NIH RO1 |
| Complement in S. Pneumoniae Otitis Media-Supplement | 3R01DC009235-02S1 | |
| The goal of this project is to explore the critical role of complement in the middle ear in host innate immunity against Streptococcus pneumoniae, a primary pathogen of otitis media. | ||
| Brad Welling, MD, PhD | 05/10/05-04/30/10 | NIH RO1 |
| Phenotypic Determinants of Vestibular Schwannomas | R01DC005985 | |
| The goal of this project is to examine the role of regulatory regions in the NF2 gene in schwannomas and further identify and understand factors which affect phenotypic expression in vestibular schwannomas. | ||
| Brad Welling, MD, PhD | 06/01/09-05/31/10 | NIDCDARRA |
| Phenotypic Determinants of Vestibular Schwannomas-Supplement | R01DC005985-05S1 | |
| The goal of this project is to examine the role of regulatory regions in the NF2 gene in schwannomas and further identify and understand factors which affect phenotypic expression in vestibular schwannomas. | ||
| Gregory Wiet, MD | 08/01/04-07/31/09 | NIH RO1 |
| Validation/Dissemination of Virtual Temporal Bone Dissection | R01DC06458 | |
| The overall goals of this project are to further develop, evaluate, and validate a virtual environment for training of surgical techniques of temporal bone surgery by residents. | ||
