Dr. Bakaletz's OSU:pro Profile

Current OSU Appointments

Professor, Pediatrics

Professor, Otolaryngology

Biographical Narrative

Research Interests: Molecular mechanisms of pathogenesis that underlie the polymicrobial disease otitis media (OM), with a particular interest in bacterial adhesins and other determinants that contribute to biofilm formation. Design, development and pre-clinical testing of vaccine candidates for the prevention of Otitis Media

Degrees

1979	B.S., The Ohio State University, Microbiology

1981	M.S., The Ohio State University, Microbiology

1984	Ph.D., The Ohio State University, Microbiology

Editorial Activities

Ad Hoc Review Board

Infection and Immunity.

Proceedings of National Academy of Sciences, U.S.A.

The Journal of Infectious Diseases.

Vaccine.

Microbial Pathogenesis.

Journal of Clinical Microbiology.

Clinical, Diagnostic and Laboratory Immunology.

Journal of Bacteriology.

Journal of the American Medical Association (JAMA).

Applied and Environmental Microbiology.

Science.

European Journal of Epidemiology.

Pharmacological Research.

Annals of Otology, Rhinology and Laryngology.

Otolaryngology - Head and Neck Surgery.

Ear, Nose and Throat Journal.

The Laryngoscope.

American Journal of Otolaryngology.

Antimicrobial Agents and Chemotherapy.

Scandinavian Journal of Infectious Diseases.

Journal of Virology.

PloS Pathogens.

Editorial Board

2008 - present

Infection and Immunity.

Inventions and Patents

Lauren Bakaletz, Inventor, Patent issued July 16, 1998. DNA molecules which encode the fimbrin protein of Haemophilus influenzae. U.S. 5,766,608.

Lauren Bakaletz, Inventor, Patent issued July 10, 2007. Genes of an otitis media isolate of nontypeable Haemophilus influenzae. U.S. 7,241,867.

Lauren Bakaletz, Inventor, Patent issued December 21, 2004. Haemophilus influenzae type IV pili. U.S. 60/532,296.

Lauren Bakaletz, Inventor, Patent issued March 25, 2003. Method for nasal application of a medicinal substance. U.S. 6,537,265.

Lauren Bakaletz, Inventor, Patent issued February 29, 2000. Method for preparing the fimbrin protein of H. influenzae. U.S. 6,030,626.

Lauren Bakaletz, Inventor, Patent issued December 11, 2007. Nontypeable H influenzae Virulence Factors. U.S. 7,306,805.

Lauren Bakaletz, Inventor, Patent issued May 13, 2003. Otitis media Vaccine. U.S. 6,562,349.

Lauren Bakaletz, Inventor, Patent issued June 12, 2007. Synthetic Chimeric Fimbrin Peptides. U.S. 7,229,622.

Lauren Bakaletz, Inventor, Patent issued December 01, 1998. Synthetic Chimeric Fimbrin Peptides. U.S. 5,843,464.

Lauren Bakaletz, Inventor, Patent issued August 20, 2002. Synthetic Chimeric Fimbrin Peptides. U.S. 6,436,405.

Memberships

2002 - present

Member. Child Health Research Career Development Award, Columbus, OH, United States. Internal Advisory Committee

2002 - 2005

Chair. Columbus Children's Research Institute, Columbus, OH, United States. Center for Perinatal Research - Institutional Biological & Chemical Safety Committee

2003	Member. Eigth International Symposium on Recent Advances in Otitis Media, Ft. Lauderdale, FL, United States. Organizing Committee

2004	Organizer. National Institutes of Health, Bethesda, MD, United States. Otitis Media Vaccines: Overcoming Obstacles to Progress

2004	Chair. National Institutes of Health, Bethesda, MD, United States. Molecular Diagnostic/Therapeutic Section, NIDCD/NIH Workshop

2005	Organizer. IDSA Annual Meeting, San Francisco, CA, United States. New Insights into and Current Challenges Presented by Polymicrobial Diseases of the Respiratory Tract

2005	Member. ASM, Kohala Coast, HI, United States. Advisory Council

2005	Member. 5th Extraordinary International Symposium on Recent Advances in Otitis Media, Amsterdam, Netherlands. Advisory Council

2005 - present

Vice Chair. Columbus Children's Research Institute, Columbus, OH, United States. Patents, Copyrights, and Conflict of Interest Committee

2006 - 2007

Member. Columbus Children's Research Institute, Columbus, OH, United States. Center for Perinatal Research

2006	Member. 6th Extraordinary International Symposium on Recent Advances in Otitis Media, Seoul, Korea. Otitis Media Program Committee

2007	Member. 9th International Symposium on Recent Advances in Otitis Media, St. Petersburg, FL, United States. Program Committee

Peer Reviewed Journal Articles

Ompremcak LB, Rheins MS. 1982. Scanning electron microscopy of mouse ciliated oviduct and tracheal epithelium infected in vitro with Bordetella pertussis. Can J Microbiol. Vol. 29: 415-420.

Bakaletz LO, Rheins MS. 1985. A whole-organ perfusion model of Bordetella pertussis adherence to mouse tracheal epithelium. In Vitro Cell Dev Biol. Vol. 21, no. 6: 314-320.

Bakaletz LO, DeMaria TF, Lim DJ. 1987. Effect of preopsonization on phagocytosis of Haemophilus influenzae. ARch Otolaryngol. Vol. 113, no. 5: 526-529.

Bakaletz LO, DeMaria TF, Lim DJ. 1987. Phagocytosis and killing of bacteria by middle ear macrophages. Arch Otolaryngol. Vol. 113, no. 2: 138-144.

Lim DJ, DeMaria TF, Bakaletz LO. 1987. Functional morphology of the tubotympanum related to otitis media: a review. Am J Otol. Vol. 8, no. 5: 385-389.

Lim DJ, DeMaria TF, Bakaletz LO. 1987. Functional morphology of the tybotympanum related to otitis media. Adv Oto-rhino-laryngol. Vol. 37: 21-25.

Bakaletz LO, Hoepf TM, DeMaria TF, Lim, DJ. 1988. The effect of antecedent influenza A virus infection on the adherence of Hemophilus influenzae to chinchilla tracheal epithelium. Am J Otolaryngol. Vol. 9, no. 3: 127-134.

Bakaletz LO, Tallan BM, Hoepf T, DeMaria TF, Birck HG, Lim DJ. 1988. Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium. Infect Immun. Vol. 56, no. 2: 331-335.

DeMaria TF, Enrique R, Dohar J, Bakaletz LO, Lim DJ. 1988. Beta 2-microglobulin in the middle ear effusions and sera from patients with chronic OME. Arch Otolaryngol. Vol. 114, no. 11: 1259-1261.

Lim DJ, DeMaria TF, Bakaletz LO. 1988. Current concepts of pathogenesis of otitis media: a review. Acta Otolaryngol. Vol. S458: 174-180.

Bakaletz LO, Griffith SR, Lim DJ. 1989. Effect of prostaglandin E2 and bacterial endotoxin on the rate of dye transport in the Eustachian tube of the chinchilla. Ann Otol Rhinol Laryngol. Vol. 98, no. 4 Pt 1: 278-282.

Bakaletz LO, Ohashi Y, Demaria TF, Lim DJ. 1989. Effect of formalin-fixed Hemophilus influenzae and Streptococcus pneumoniae on dye transport by the chinchilla Eustachian tube. Acta Otolaryngol (Stockh). Vol. 107, no. 3-4: 235-243.

Bakaletz LO, Tallan BM, Andrzejewski WJ, DeMaria TF, Lim DJ. 1989. Immunological responsiveness of chinchillas to outer membrane and isolated fimbrial proteins of nontypeable Haemophilus influenzae. Infect Immun. Vol. 57, no. 10: 3226-3229.

Ogra PL, Giebink GS, Barenkamp SJ, DeMaria TF, Juhn SK, Shurin PA, Andersson B, Bakaletz LO, Bernstein JM, Brinton CC. 1989. Recent advances in otitis media. Microbiology, immunology, biochemistry, and vaccination. Ann Otol Rhinol Laryngol. Vol. 139: 23-32.

Liauw L, Lim DJ, Bakaletz LO, van Blitterswijk C. 1991. Effect of vitamin A on the growth and differentiation of rat external auditory canal epithelium in organ culture. Amer J Otolaryngol. Vol. 12, no. 2: 67-75.

Lim DJ, Coticchia JM, Ueno K, Heiselman FA, Bakaletz LO. 1991. Glycoconjugates in the chinchilla tubotympanum. Ann Otol Rhinol Laryngol. Vol. 100, no. 11: 933-943.

Bakaletz LO, Ahmed MA, Kolattukudy PE, Lim DJ, Forney LJ. 1992. Cloning and sequence analysis of a pilin-like gene from an otitis media isolate of nontypeable Haemophilus influenzae. J Infect Dis. Vol. 165 Suppl 1: S201-S203.

DeMaria TF, Yamaguchi T, Bakaletz LO, Lim DJ. 1992. Serum and middle ear antibody response in the chinchilla during otitis media with effusion induced by nonviable nontypeable Haemophilus influenzae. J Infect Dis. Vol. 165 Suppl 1: S196-S197.

Gilsdorf JR, Chang HY, McCrea KW, Bakaletz LO. 1992. Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae. Infect Immun. Vol. 60, no. 2: 374-379.

Lim DJ, Bakaletz LO. 1992. An investigation of the molecular basis of nontypable Haemophilus influenzae adherence to mucosal epithelium. Rhinology, Supplement. Vol. 14: 37-41.

Bakaletz LO, Daniels RL, Lim DJ. 1993. Modeling adenovirus type 1-induced otitis media in the chinchilla: effect on ciliary activity and fluid transport function of Eustachian tube mucosal epithelium. The Journal of infectious diseases. Vol. 168, no. 4: 865-872.

Park K, Bakaletz LO, Coticchia JM, Lim DJ. 1993. Effect of influenza A virus on ciliary activity and dye transport function in the chinchilla Eustachian tube. Ann Otol Rhinol Laryngol. Vol. 102, no. 7: 551-558.

Bakaletz LO, Barenkamp SJ. 1994. Localization of high molecular weight adhesion proteins of nontypable Haemophilus influenzae by immunoelectron microscopy. Infect Immun. Vol. 62, no. 10: 4460-4468.

Hesseling SC, van Blitterswijk CA, Lim DJ, DeMaria TF, Bakaletz LO, Grote JJ. 1994. The effect of endotoxin on cultured rat middle ear epithelium, rat meatal epidermis and human keratinocytes. Amer J Otology. Vol. 15, no. 6: 762-768.

Kunin CM, Hua T, Bakaletz LO, Guerrant RL. 1994. Effect of salicylate, bismuth, osmolytes, and tetracycline resistance on expression of fimbriae by Escherichia coli. Infect Immun. Vol. 62, no. 6: 2178-2186.

Sirakova T, Kolattukudy PE, Murwin D, Billy J, Leake E, Lim DJ, DeMaria TF, Bakaletz LO. 1994. The role of fimbriae expressed by nontypeable Haemophilus influenzae in the pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A. Infect immun. Vol. 62, no. 5: 2002-2020.

Suzuki K, Bakaletz LO. 1994. Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media. Infect Immun. Vol. 62, no. 5: 1710-1718.

Bakaletz LO, Murwin DM, Billy JM. 1995. Adenovirus serotype 1 does not act synergistically with Moraxella catarrhalis to induce otitis media in the chinchilla. Infect Immun. Vol. 63, no. 10: 4188-4190.

Bakaletz LO. 1995. Viral potentiation of bacterial superinfection of the airway. Trends Microbiol. Vol. 3, no. 3: 110-114.

Karma PH, Bakaletz LO, Giebink GS, Mogi G, Rynnel-Dagöö B. 1995. Immunological aspects of otitis media with special reference to immunoprophylaxis of acute otitis media in infants and children. Intl J Ped Otolaryngol. Vol. 32: S127-S134.

Kunin CM, Tong H-H, Bakaletz LO. 1995. Effect of salicylate on expression of flagella by Escherichia coli, Proteus, Providencia and Pseudomonas. Infect Immun. Vol. 63, no. 5: 1796-1799.

Miyamoto N, Bakaletz LO. 1996. Selective adherence of nontypeable H.influenzae (NTHi) to mucus or epithelial cells in the chinchilla Eustachian tube and middle ear. Microb Pathog. Vol. 21, no. 5: 343-356.

Bakaletz LO, Holmes KA. 1997. Evidence of transudation of specific antibody into the middle ears of parenterally immunized chinchillas after an upper respiratory tract infection with adenovirus. Clin Diag Lab Immunol. Vol. 4, no. 2: 223-225.

Bakaletz LO, Leake ER, Billy JM, Kaumaya PTP. 1997. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine. Vol. 15, no. 9: 955-961.

Holmes K, Bakaletz LO. 1997. Adherence of nontypeable H. influenzae promotes re-organization of the actin cytoskeleton in human or chinchilla epithelial cells in vitro. Microb Pathog. Vol. 23, no. 3: 157-166.

Miyamoto N, Bakaletz LO. 1997. Kinetics of the ascension of NTHi from the nasopharynx to the middle ear of the chinchilla coincident with adenovirus-induced compromise. Microb Pathog. Vol. 23, no. 2: 119-126.

Welling DB, Parnes LS, O'Brien B, Bakaletz LO, Brackmann DE, Hinojosa R. 1997. Particulate matter in the posterior semicircular canal. Laryngoscope. Vol. 107, no. 1: 90-94.

Bakaletz LO, Post JC, Ehrlich GD. 1998. 1998. Blinded multiplex PCR analysis of middle ear and nasopharyngeal fluids recovered from experimental chinchilla models of single and mixed pathogen induced otitis media. Vol. 5, no. 2: 219-224.

Bakaletz LO, Kennedy BJ, Novotny LA, Dequesne G, Cohen J, Lobet Y. 1999. Protection against development of otitis media induced by nontypeable H. influenzae by both active and passive immunization in a chinchilla model of viral-bacterial superinfection. Infect Immun. Vol. 67, no. 6: 2746-2762.

Jiang A, Nagata N, Molina E, Bakaletz LO, Hawkins H, Patel JA. 1999. Fimbriae-mediated enhanced attachment of nontypeable Haemophilus influenzae to respiratory syncytial virus-infected respiratory epithelial cells. Infect Immun. Vol. 67, no. 1: 187-192.

Kennedy B, Novotny LA, Jurcisek JA, Lobet Y, Bakaletz LO. 2000. Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge. Infect Immun. Vol. 68, no. 5: 2756-2765.

Novotny LA, Jurcisek JA, Bakaletz LO. 2000. Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae. Infect Immun. Vol. 68, no. 4: 2119-2128.

Poolman JT, Bakaletz LO, Cripps A, Denoël P, Forsgren A, Kyd J, Lobet Y. 2000. Developing a nontypeable Haemophilus influenzae (NTHi) vaccine. Vaccine. Vol. 19, no. Suppl 1: S108.

Bakaletz LO. 2001. Peptide and recombinant antigens for protection against bacterial middle ear infection. Vaccine. Vol. 19, no. 17-19: 2323-2328.

Novotny LA, Pichichero ME, Denoel PA, Neyt C, Vanderschrick S, Dequesne G, Bakaletz LO. 2002. Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media. Vaccine. Vol. 20, no. 29-30: 3590-3597.

Visweswaraiah A, Novotny LA, Hjemdahl-Monsen EJ, Bakaletz LO, Thanavala Y. 2002. Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention. Vaccine. Vol. 20, no. 25-26: 3209-3220.

Jurcisek JA, Durbin JE, Kusewitt DF, Bakaletz LO. 2003. Anatomy of the nasal cavity in the chinchilla. Cell, Tissues, Organs. Vol. 174, no. 3: 136-152.

Kyd JM, Cripps AW, Novotny LA, Bakaletz LO. 2003. Efficacy of OMP26 and two P5-fimbrin derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx. Infect Immun. Vol. 71, no. 8: 4691-4699.

Mason KM, Munson RS, Bakaletz LO. 2003. Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media. Infect Immun. Vol. 71, no. 6: 3454-3462.

Novotny LA, Bakaletz LO. 2003. The fourth surface-exposed region of the OMP P5-homologous adhesin of nontypeable H. influenzae is an immunodominant but non-protective decoy epitope. J Immunol. Vol. 71, no. 4: 1978-1983.

Bakaletz LO. 2004. Developing animal models for polymicrobial diseases. Nat Rev Microbiol. Vol. 2, no. 7: 552-568.

Harris RH, Wilk D, Bevins CL, Munson Jr RS, Bakaletz LO. 2004. Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. J Biol Chem. Vol. 279, no. 19: 20250-20256.

Morton DJ, Bakaletz LO, Jurcisek JA, Van Wagoner TM, Seale TW, Whitby PW, Stull TL. 2004. Reduced severity of middle ear infection caused by NTHI lacking the hemoglobin/ hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media. Microb Path. Vol. 36, no. 1: 25-33.

Munson Jr RS, Harrison A, Gillaspy A, Ray WC, Carson M, Armbruster D, Gipson J, Gipson M, Johnson L, Lewis L, Dyer DW, Bakaletz LO. 2004. Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates. Infect Immun. Vol. 72, no. 5: 3002-3010.

Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R, Munson Jr RS. 2005. Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae. Infect Immun. Vol. 73, no. 3: 1635-1643.

Barenkamp SJ, Kurono Y, Ogra PL, Leiberman, A, Bakaletz LO, Murphy TF, Chonmaitree T, Patel JA, Heikkinen T, Sih TM, Hurst DS, St Geme 3rd JW, Kawauchi H, Stenfors L-E. 2005. Recent advances in otitis media. 5. Microbiology and immunology.  Ann Otol Rhinol Laryngol. Supplement. Vol. 194: 60-85.

Giebink GS, Kurono Y, Bakaletz LO, Kyd JM, Barenkamp SJ, Murphy TF, Green B, Ogra PL, Gu X-X, Patel JA, Heikkinen T, Pelton SI, Hotomi M, Karma P. 2005. Recent advances in otitis media. 6. Vaccine.  Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194: 86-103.

Gitiban N, Jurcisek JA, Harris RH, Mertz S, Durbin RK, Bakaletz LO, Durbin JE. 2005. Chinchilla and murine models of upper respiratory tract infection with respiratory syncytial virus.  J Virol. Vol. 79, no. 10: 6035-6042.

Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO, Munson Jr. RS. 2005. The genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.  Journal of bacteriology. Vol. 187, no. 13: 4627-4636.

Jurcisek JA, Greiner L, Watanabe H, Zaleski A, Apicella MA, Bakaletz LO. 2005. The role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.  Infect Immun. Vol. 73, no. 6: 3210-3218.

Lim DJ, Hermansson A, Hellstrom SO, Hussl B, Alper CM, Iino Y, Andalibi A, Jung TTK, Bakaletz LO, Kawauchi H, Buchman CA, Kerschner J, Caye-Thomasen P, Lin J, Chole RA, Merchant SN, Herman P, Paparella MM, Lee H-Y, Kang S-H. 2005. Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics.  Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194: 31-41.

Mason KM, Munson Jr RS, Bakaletz LO. 2005. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.  Infect Immun. Vol. 73, no. 1: 599-608.

Murphy TF, Bakaletz LO, Kyd JM, Watson B, Klein DL. 2005. Vaccines for otitis media: proposals for overcoming obstacles to progress.  Vaccine. Vol. 23, no. 21: 2696-2702.

Novotny LA, Mason KM, Bakaletz LO. 2005. Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.  Infect Immun. Vol. 73, no. 1: 609-611.

Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. 2005. Recent advances in otitis media. 4A. Molecular biology.  Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194: 42-49.

Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. 2005. Recent advances in otitis media. 4B. Biochemistry.  Ann Otol Rhinol Laryngol. Supplement. Vol. 194: 50-55.

Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. 2005. Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media.  Ann Otol Rhinol Laryngol. Supplement. Vol. 194: 56-59.

Avadhanula A, Rodriguez CA, Ulett GC, Bakaletz LO, Adderson EE. 2006. Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression.  Infect Immun. Vol. 74, no. 2: 830-838.

Mason KM, Bruggeman ME, Munson Jr RS, Bakaletz LO. 2006. The nontypeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition.  Mol Micro. Vol. 62, no. 5: 1357-1372.

Novotny LA, Jurcisek JA, Godfroid F, Poolman JT, Denoel PA, Bakaletz LO. 2006. Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae.  Vaccine. Vol. 24, no. 22: 4804-4811.

Wang HH, Manuzon M, Lehman M, Wan K, Luo H, Wittum TE, Yousef A, Bakaletz LO. 2006. Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes.  FEMS Microb Lett. Vol. 254, no. 2: 226-231.

Bakaletz LO. 2007. Bacterial biofilms in otitis media: evidence and relevance.  Pediatr Infect Dis J. Vol. 26, no. 10 Suppl: S17-S19.

Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO, Munson Jr RS. 2007. The OxyR regulon in nontypeable Haemophilus influenzae.  J Bacteriol. Vol. 189, no. 3: 1004-1012.

Hong W, Mason KM, Jurcisek JA, Novotny LA, Bakaletz LO, Swords WE. 2007. Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media.  Infect Immun. Vol. 75, no. 2: 958-965.

Jewell NA, Vaghefi N, Mertz SE, Akter P, Peebles Jr RS, Bakaletz LO, Durbin RK, Flano E, Durbin JE. 2007. Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo.  J Virol. Vol. 81, no. 18: 9790-9800.

Jurcisek JA, Bakaletz LO. 2007. Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein.  Journal of bacteriology. Vol. 189, no. 10: 3868-3875.

Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS Jr, Bakaletz LO. 2007. The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.  Mol Micro. Vol. 65, no. 5: 1288-1299. (IF: 5.634)

Luke NR, Jurcisek JA, Bakaletz LO, Campagnari AA. 2007. Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation.  Infect Immun. Vol. 75, no. 12: 5559-5564.

McGillivary G, Ray WC, Bevins CL, Munson Jr RS, Bakaletz LO. 2007. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.  Mol Immunol. Vol. 44, no. 9: 2446-2458.

Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO. 2008. A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the OMP P5-homologous adhesin.  Infect Immun. Vol. 76, no. 1: 48-55.

Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO. 2008. Spotlight.  Infect Immun. Vol. 76, no. 1: 21. (IF: 3.996)

McGillivary G, Bakaletz LO. 2008. Innate immune defenses: finding a new way to calm the storm. Immunol Cell Biol. Vol. 86, no. 8: 639-640. (IF: 3.033)

Novotny LA, Partida-Sanchez S, Munson Jr RS, Bakaletz LO. 2008. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.  Infect Immun. Vol. 76, no. 3: 967-977. (IF: 3.996)

Bakaletz LO. 2009. Development and use of the chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention. Expert Rev Vaccines. (Revised submission)

Hoopman TC, Liu W, Sedillo JL, Labandeira-Rey M, Laurence CA, Wang W, Richardson JA, Bakaletz LO, Hansen EJ. 2009. Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis. Infect Immun. (First submission)

Jurcisek JA, Grieves JL, Bruggeman ME, Bakaletz LO. Mucosal delivery of antibodies directed against the nontypeable Haemophilus influenzae pilin protein prevents biofilm formation and eradicates established biofilms in the chinchilla middle ear. TBD. (Forthcoming)

Jurcisek JA, Grieves JL, Quist B, Durbin JE, Peeples ME, Bakaletz LO. 2009. Mapping the anatomy of respiratory syncytial virus infection in the chinchilla upper airway. Am J Pathol. (Revised submission)

Jurcisek JA, McGillivary G, Bakaletz LO. 2009. Neutrophil NETs associated with biofilms formed by nontypeable Haemophilus influenza incorporate antimicrobial peptides. J of Innate Immun. (First submission)

McGillivary G., Mason KM, Jurcisek JA, Peeples ME, Bakaletz LO. RSV-induced dysregulation of expression of a mucosal β-defensin augments colonization of the upper airway by nontypeable Haemophilus influenzae. Cell Micro. Vol. MS# CMI-09-0052.R1, no. doi: 10.1111/j.1462-5822.2009.01339.x. (In press)

Morton DJ, Seale TW, Bakaletz LO, Jurcisek JA, Smith A, VanWagoner TM, Whitby PW, Stull TL. The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant. Int J Med Microbiol, no. doi:10.1016/j.ijmm.2009.03.004. (In press)

Murphy TF, Bakaletz LO, Smeesters P. 2009. Microbial interactions in the respiratory tract. Pediatr Infect Dis J. (Revised submission)

Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, Virji M, Pelton SI. 2009. Nontypeable Haemophilus influenzae as a pathogen in children. Pediatr Infect Dis J. Vol. 28, no. 1: 43-48. (IF: 3.086)

Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz L.O. 2009. Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates. Vaccine. (Revised submission)

Novotny LA, Hill SR, Fening KM, Bakaletz LO. 2009. Intranasal immunization with a P5-derived immunogen induces rapid clearance of nontypeable Haemophilus influenzae from the chinchilla nasopharynx and middle ear. Mucosal Immunology. (First submission)

Positions

1985 - 1986

Postdoctoral Researcher, The Ohio State University, College of Medicine, Otological Research Laboratories, Department ofOtolaryngology. Columbus, OH, United States.

1986 - 1987

Senior Research Associate, The Ohio State University, College of Medicine, Otological Research Laboratories, Department of Otolaryngology. Columbus, OH, United States.

1987 - 1993

Assistant Professor, The Ohio State University, College of Medicine, Otological Research Laboratories, Department of Otolaryngology. Columbus, OH, United States.

1993 - 1998

Associate Professor, The Ohio State University, College of Medicine, Otological Research Laboratories Department of Otolaryngology. Columbus, OH, United States.

1996 - 1998

Head, The Ohio State University, College of Medicine, Division of Otologic Research, Department of Otolaryngology, Microbial Pathogenesis Section. Columbus, OH, United States.

1998 - 2000

Associate Professor, The Ohio State University, O.S.U.College of Medicine & Public Health, Children’s Research Institute, Division of Molecular Medicine, Department of Pediatrics. Columbus, OH, United States.

2000 - 2007

Professor, The Ohio State University, The Ohio State University College ofMedicine/Columbus Children’s Research Institute, Divison of Molecular Medicine, Department of Pediatrics. Columbus, OH, United States.

2003 - 2007

Director, Center for Microbial Pathogenesis, Columbus Children’s Research Institute. Columbus, OH, United States.

2006 - 2007

Vice-President for Basic Science Research, Columbus Children’s Research Institute. Columbus, OH, United States.

2006 - 2007

Tillie E. Coleman Endowed Chair in Pediatric Research, Columbus Children's Hospital. Columbus, OH, United States.

2006 - present

Member, The Ohio State University, Center for Microbial Interface Biology. Columbus, OH, United States.

2007 - present

Professor, The Ohio State University, The Ohio StateUniversity College of Medicine/The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics and Department of Otolaryngology. Columbus, OH, United States.

2007 - present

Director, Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital. Columbus, OH, United States.

2007 - present

Vice-President for Basic Science Research, The Research Institute at Nationwide Children's Hospital. Columbus, OH, United States.

2007 - present

Tillie E. Coleman Endowed Chair in Pediatric Research, Nationwide Children's Hospital. Columbus, OH, United States.