Children's Hospital
700 Childrens Dr
Columbus, OH 43205
Phone: (614) 722-2804
Email: chang.22@osu.edu
Current OSU Appointments
Professor, Pediatrics
Professor, Molecular & Cellular Biochemistry
Professor, Otolaryngology
Certifications
| Certificate in Computer Programming: Electrical Engineering, National Taiwan University |
| Training Course in Molecular Cloning of Eukaryotic Genes: Cold Spring Harbor Laboratory |
| Training Course in Medical and Experimental Mammalian Genetics: Jackson Laboratory |
Chapters In Books
D.B.Welling, M.D. Packer, E.M. Akhmametyeva, Long-Sheng Chang. 2007. The Biology and Genetics of Vestibular Schwannomas. In Tumors of the Cerebellopontine Angle. Edited by NC Bambakidis, Porter Megerian, RF Spetzler. Hamiliton, Ontario, Canada: B.C. Decker, Inc.
Chang LS, Welling DB. 2008. Biology of Vestibular Schwannomas. In Auditory/Vestibular Research. Edited by Sokolowski, B. Totowa, NJ: The Humana Press. 163-177.
Degrees
| 1978 | B.S., National Taiwan University, Medical Technology |
| 1984 | Ph.D., University of Medicine and Dentistry of New Jersey, Microbiology |
| 1990 | Postdoctoral, Princeton University, Molecular Biology |
Editorial Activities
Ad Hoc Journal Reviewer
| 1993 | FASEB Journal. |
| 1992 | Journal of Virology. |
| 1987 - 1990 | Journal of Virology. |
Ad Hoc Reviewer
| 2003 | National Science Foundation, Biochemistry and Gene Expression Program. |
| 1996 | Molecular & Cellular Biology Journal. |
| 1996 | National Science Foundation. |
Journal Reviewer
| 2008 | Oncogene. |
Peer Reviewer
| 2007 | The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 2. |
| 2007 | The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 4. |
| 2005 | Panel Member, Cancer Research Program, The US Army Medical Research and Material Command (USAMRMC) Congressionally Directed Medical Research Program (CDMRP). |
Referee
| 2006 | Grants Committee, Medical Research Council, UK. |
| 2005 | Project Grants Committee, Cancer Research UK. |
Reviewer
| 2008 | Neuroscience Letters. |
| 2007 | International Journal of Bioinformatics Research and Applications (IJBRA). |
| 2006 - 2007 | Audiology and Neurotology. |
| 2006 | Cerebral Cortex. |
| 2006 | Cerebral Cortex. |
| 2006 | Human Molecular Genetics. |
| 2006 | Experimental Cell Research. |
| 2006 | Neurology India. |
| 2006 | Neuroscience Letters. |
| 2005 | Molecular Cellular Biochemistry. |
| 2005 | Oncogene. |
| 2004 | Cellular and Molecular Life Sciences. |
| 2004 | Brain Research Molecular Brain Research. |
| 2004 | Neurology India. |
| 2004 | Molecular Cellular Biochemistry. |
| 2004 | Glia. |
| 2003 | Molecular and Cellular Biology. |
Scientific Reviewer
| 2007 | The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 4. |
Honors
| 1976 | Book Coupon Award. National Taiwan University. National Taiwan University, Taipei, Taiwan, Province of China. |
| 1979 - 1983 | Graduate Assistantship. University of Medicine and Dentistry of New Jersey, Newark, NJ, United States. Subject: Graduate School of Biomedical Sciences |
| 1985 - 1987 | Leukemia Society Research Fellowship. Leukemia Society of America. |
Inventions and Patents
Long-Sheng Chang and Lingyun Zhu, Patent issued 1998. Transgenic Mice Which Express Simian SV 40 T-Antigen Under Control of the Retinoblastoma Gene Promoter. 5,728,915.
Thomas Shenk, Richard Jude Samulski, and Long-Sheng Chang, Patent issued 1996. Helper-Free Stocks of Recombinant Adeno-Associated Virus Vectors. 5,436,146.
Thomas Shenk, Richard Jude Samulski, and Long-Sheng Chang, Patent issued 1998. Helper-Free Stocks of Recombinant Adeno-Associated Virus Vectors. 5,753,500. The Trustees of Princeton University, Princeton, NJ.
Thomas Shenk, Richard Jude Samulski, and Long-Sheng Chang, Patent issued 2002. Helper-Free Stocks of Recombinant Adeno-Associated Virus Vectors. 6,489,162. The Trustees of Princeton University, Princeton, NJ.
Memberships
| Member. American Association for the Advancement of Sciences (AAAS) |
| Member. American Association for Cancer Research (AACR) |
| Member. American Society of Microbiology (ASM) |
| Member. American Society of Cell Biology (ASCB) |
| Member. Human Genome Organization (HUGO) |
| Member. National Geographic Society |
| Member. Society for Neuroscience (SFN) |
Peer Reviewed Journal Articles
Shi Y; Seto E; Chang LS; Shenk T. 1991. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell. Vol. 67, no. 2. (October 18): 377.
Parks CL; Chang LS; Shenk T. 1991. A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region. Nucleic Acids Research. Vol. 19, no. 25. (December 1): 7155.
Yang CL; Chang LS; Zhang P; Hao H; Zhu L; Toomey NL; Lee MY. 1992. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta. Nucleic Acids Research. Vol. 20, no. 4. (February 25): 735.
Sung LA; Chien S; Fan YS; Lin CC; Lambert K; Zhu L; Lam JS; Chang LS. 1992. Human erythrocyte protein 4.2: isoform expression, differential splicing, and chromosomal assignment. Blood. Vol. 79, no. 10. (May 15): 2763.
Mannherz AN. 1993. Managing the design and implementation of an agrochemical central sample preparation laboratory. The Journal Of Automatic Chemistry. Vol. 15, no. 1. (January 1): 19.
Zhang SJ; Zeng XR; Zhang P; Toomey NL; Chuang RY; Chang LS; Lee MY. 1995. A conserved region in the amino terminus of DNA polymerase delta is involved in proliferating cell nuclear antigen binding. The Journal Of Biological Chemistry. Vol. 270, no. 14. (April 7): 7988.
Karacay B; Xie E; Chang LS. 1995. The murine erythrocyte protein-4.2-encoding gene: similarities and differences in structure and expression from its human counterpart. Gene. Vol. 158, no. 2. (June 9): 253.
Zhu L; Zhu L; Xie E; Chang LS. 1995. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Molecular And Cellular Biology. Vol. 15, no. 7. (July 1): 3552.
Chang LS; Zhao L; Zhu L; Chen ML; Lee MY. 1995. Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1). Genomics. Vol. 28, no. 3. (August 10): 411.
Xie E; Zhu L; Zhao L; Chang LS. 1996. The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant. Genomics. Vol. 35, no. 3. (August 1): 551.
Zhao L; Chang LS. 1997. The human POLD1 gene. Identification of an upstream activator sequence, activation by Sp1 and Sp3, and cell cycle regulation. The Journal Of Biological Chemistry. Vol. 272, no. 8. (February 21): 4869.
Lee Y; Chen Y; Chang LS; Johnson LF. 1997. Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein. Experimental Cell Research. Vol. 234, no. 2. (August 1): 270.
Zhu L; Kahwash SB; Chang LS. 1998. Developmental expression of mouse erythrocyte protein 4.2 mRNA: evidence for specific expression in erythroid cells. Blood. Vol. 91, no. 2. (January 15): 695.
Karacay B; Chang LS. 1999. Induction of erythrocyte protein 4.2 gene expression during differentiation of murine erythroleukemia cells. Genomics. Vol. 59, no. 1. (July 1): 6.
Welling DB; Chang LS. 2000. All in a name: schwannomin versus merlin. The American Journal Of Otology. Vol. 21, no. 2. (March 1): 289.
Mao Y; Okada S; Chang LS; Muller MT. 2000. p53 dependence of topoisomerase I recruitment in vivo. Cancer Research. Vol. 60, no. 16. (August 15): 4538.
Reshetnikova G; Barkan R; Popov B; Nikolsky N; Chang LS. 2000. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein. Experimental Cell Research. Vol. 259, no. 1. (August 25): 35.
Welling DB; Akhmametyeva EM; Daniels RL; Lasak JM; Zhu L; Miles-Markley BA; Chang LS. 2000. Analysis of the human neurofibromatosis type 2 gene promoter and its expression. Otolaryngology--Head And Neck Surgery: Official Journal Of American Academy Of Otolaryngology-Head And Neck Surgery. Vol. 123, no. 4. (October 1): 413.
Chang LS; Akhmametyeva EM; Wu Y; Zhu L; Welling DB. 2002. Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts. Genomics. Vol. 79, no. 1. (January 1): 63.
Lasak JM; Welling DB; Akhmametyeva EM; Salloum M; Chang LS. 2002. Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomas. The Laryngoscope. Vol. 112, no. 9. (September 1): 1555.
Welling DB; Lasak JM; Akhmametyeva E; Ghaheri B; Chang LS. 2002. cDNA microarray analysis of vestibular schwannomas. Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology. Vol. 23, no. 5. (September 1): 736.
Lo WD; Akhmametyeva EM; Zhu L; Friesen PD; Chang LS. 2003. Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cells. Brain Research. Molecular Brain Research. Vol. 113, no. 1-2. (May 12): 1.
Xu Z; Huang S; Chang LS; Agulnick AD; Brandt SJ. 2003. Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation. Molecular And Cellular Biology. Vol. 23, no. 21. (November 1): 7585.
Popov B; Chang LS; Serikov V. 2005. Cell cycle-related transformation of the E2F4-p130 repressor complex. Biochemical And Biophysical Research Communications. Vol. 336, no. 3. (October 28): 762.
Jiang Y; Lo W; Akhmametyeva EM; Chang LS. 2006. Over-expression of p73beta results in apoptotic death of post-mitotic hNT neurons. Journal Of The Neurological Sciences. Vol. 240, no. 1-2. (January 15): 1.
Neff BA; Welling DB; Akhmametyeva E; Chang LS. 2006. The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level. Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology. Vol. 27, no. 2. (February 1): 197.
Neff BA; Oberstien E; Lorenz M; Chaudhury AR; Welling DB; Chang LS. 2006. Cyclin D(1) and D(3) expression in vestibular schwannomas. The Laryngoscope. Vol. 116, no. 3. (March 1): 423.
Akhmametyeva EM; Mihaylova MM; Luo H; Kharzai S; Welling DB; Chang LS. 2006. Regulation of the neurofibromatosis 2 gene promoter expression during embryonic development. Developmental Dynamics: An Official Publication Of The American Association Of Anatomists. Vol. 235, no. 10. (October 1): 2771.
Chang LS; Jacob A; Lorenz M; Rock J; Akhmametyeva EM; Mihai G; Schmalbrock P; Chaudhury AR; Lopez R; Yamate J; John MR; Wickert H; Neff BA; Dodson E; Welling DB. 2006. Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency mice. The Laryngoscope. Vol. 116, no. 11. (November 1): 2018.
Welling DB, Packer MD, Chang LS. 2007. Molecular studies of vestibular schwannomas: a review. Current Opinion in Otolaryngology & Head and Neck Surgery. Vol. 15, no. 5: 341-346.
Welling, D Bradley; Packer, Mark, D; Chang, Long-Sheng. 2007. Molecular studies of vestibular schwannomas: a review. Current opinion in otolaryngology & head and neck surgery. Vol. 15, no. 5. (IF: 1.338)
Welling DB; Packer MD; Chang LS. 2007. Molecular studies of vestibular schwannomas: a review. Current Opinion In Otolaryngology & Head And Neck Surgery. Vol. 15, no. 5. (October 1): 341.
Kopyl SA, Dorogova NV, Baymak TY, Chang LS, Omelyanchuk LV. 2008. The Role of Porcupine Gene In the Development of Wing Imaginal Disc of Drosophila Melanogaster. Genetica. Vol. 44: 1-7. (IF: 1.396)
Yudina OS, Gusachenko AM, Akhmameteva Em, Omelyanchuk LV, Chang LS. 2008. Chromosome non-disjunction in tumor-suppressor Merlin mutant strains. J. Genet.. Vol. 44: 357-359. (IF: 0.567)
Dorogova NV, Akhmameteva EM, Kopyl SA, Gubanova NV, Yudina OS, Omelyanchuk LV, Chang LS. 2008. The Role of Drosophila Merlin in Spermatogenesis. BMC Cell Biol.. Vol. 9. (January): 1-15. (IF: 3.092)
Jacob A, Lee TX, Neff BA, Miller S, Welling DB, Chang LS. 2008. Activation of the AKT Pathway in Human Vestibular Schwannomas. Otol. Neurotol.. Vol. 29. (January): 58-68. (IF: 1.410)
Jacob A; Lee TX; Neff BA; Miller S; Welling B; Chang LS. 2008. Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology. Vol. 29, no. 1. (January 1): 58.
Jacob A; Lee TX; Neff BA; Miller S; Welling B; Chang LS. 2008. Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology. Vol. 29, no. 1. (January 1): 58. (IF: 1.410)
Kopyl SA; Dorogova NV; Baimak TIu; Chang LS; Omel'ianchuk LV. 2008. [Role of the porcupine gene in the development of the wing imaginal disk of Drosophila melanogaster]. Genetika. Vol. 44, no. 11. (November 1): 1486.
Chang LS; Welling DB. 2009. Molecular biology of vestibular schwannomas. Methods In Molecular Biology (Clifton, N.J.). Vol. 493. (January 1): 163.
Positions
| 1977 - 1978 | Undergraduate Thesis Research, National Taiwan University, College of Medicine, Graduate Institute of Bacteriology. Taipei, Taiwan, Province of China. |
| 1978 - 1979 | Medical Technologist, National Taiwan University, Medical Technology. Taipei, Taiwan, Province of China. |
| 1979 - 1984 | Ph.D. Research, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Microbiology. Newark, NJ, United States. |
| 1984 | Research Associate, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Microbiology. Newark, NJ, United States. |
| 1985 | Research Associate, Princeton University, Molecular Biology. Princeton, NJ, United States. |
| 1985 - 1987 | Leukemia Society Research Fellow, Princeton University. Princeton, NJ, United States. |
| 1988 - 1990 | Research Staff Member, Princeton University, Department of Molecular Biology. Princeton, NJ, United States. |
| 1990 - 1996 | Assistant Professor, The Ohio State University College of Medicine, Department of Pediatrics. Columbus, OH, United States. |
| 1991 - 1995 | Laboratory Director, The Ohio State University, Children's Hospital Transgenic Mouse Facility. Columbus, OH, United States. |
| 1991 - 1996 | Adjunct Assistant Professor, The Ohio State University, College of Medicine, Department of Medical Biochemistry. Columbus, OH, United States. |
| 1995 - 1996 | Laboratory Director, The Ohio State University, The Ohio State University Comprehensive Cancer Center Transgenic Mouse Facility at Children's Hospital. Columbus, OH, United States. |
| 1996 - present | Associate Professor, The Ohio State University, Department of Pediatrics Children's Hospital. Columbus, OH, United States. |
| 1996 - 2007 | Associate Professor, The Ohio State University, Department of Pediatrics Children's Hospital. Columbus, OH, United States. |
| 1996 - 2007 | Adjunct Associate Professor, The Ohio State University, College of Medicine, Department of Molecular Cellular Biochemistry (former Medical Biochemistry). Columbus, OH, United States. |
| 1998 - 2007 | Adjunct Associate Professor, The Ohio State University, College of Medicine, Department of Pathology. Columbus, OH, United States. |
| 2001 - 2007 | Adjunct Associate Professor, The Ohio State University, College of Medicine, Department of Otolaryngology. Columbus, OH, United States. |
| 2003 - 2007 | Adjunct Associate Professor, The Ohio State University, Department of Veterinary Biosciences. Columbus, OH, United States. |
| 2007 - present | Professor, The Ohio State University, College of Medicine, and Center for Childhood Cancer, Children’s Research Institute, Department of Pediatrics. Columbus, OH, United States. |
| 2007 - present | Adjunct Professor, The Ohio State University, Departments of Molecular Cellular Biochemistry, Pathology, Otolaryngology, and Vet. Biosci. Columbus, OH, United States. |
Presentations
Other Presentations
Local
Chang, L.-S., J.D. Martinez, A.J. Levine, and T.E. Shenk, Presenter. 1990. Suppression of Transformation of SV40 T- and Adenovirus E1- Transformed Human Cells by the Wild-Type Human RB and p53 Genes. Presented at The 4th Annual DNA Viruses and Gene Expression Group-The Stone Laboratory Meeting,. The Ohio State University. Columbus, OH.
Chang, L.-S, Presenter. 1991. Gene Therapy for Cancer Using Adeno-Associated Virus Vectors Carrying the Retinoblastoma and p53 Suppressor Genes. Presented at Wexner International Exchange Program Research Colloquium. Children's Hospital. Columbus, OH.
Chang, L.-S, Presenter. 1991. Gene Therapy for Cancer Using Human Adeno-Associated Virus Vectors Carrying the Retinoblastoma and p53 Suppressor Genes. Presented at Wexner International Exchange Program Research Colloquium. Children's Hospital. Columbus, OH.
Uselman, J., C. Boesel, E. Kosnik, M. Miner, M.S. O'Dorisio, and L.-S. Chang, Discussant. 1991. The Retinoblastoma and P53 Suppressor Genes in Pediatric Nervous System Tumors. Presented at Twelfth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Wenger, G.D., M.S. O'Dorisio, S.J. Qualman, L.-S. Chang, J. Jackson, J. Labanowska, Presenter. 1991. VIP: Possible Autocrine Growth Factor in Neuroblastoma. Presented at Twelfth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Williams, L.L., H.M. Lew, J.S. Wolinsky, L.-S. Chang, F.H. Davidorf, and R.B. Chambers, Presenter. 1991. Cultured Human Retinal Pigment Epithelial Cells: Rubella Virus Infection Is Chronic/Persistent and Difficult to Recognize. Presented at Twelfth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Chang, L.-S., L. Zhu, J.H. Uselman, H.-D. Wang, R.-Y. Chuang, M.-L. Chen, and D.-Y. Lu., Presenter. 1992. Oncogenes, Anti-Oncogenes, and Transcription Factors. Presented at Ohio Symposium on Advances in Science and Technology. Columbus, OH.
Chang, L.-S., L. Zhu, R. Chen, J.S. Lam, M.-L. Chen, and M.Y.W.T. Lee, Presenter. 1992. Expression of the Human DNA Polymerase Gene in Normal and Transformed Cells. Presented at Thirteenth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Chuang, R.-Y. and L.-S. Chang, Presenter. 1992. Production of Large Quantity of Growth Regulatory Proteins, RB, p53, YY1, and Pol , in Baculovirus. Presented at Thirteenth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Chuang, R.-Y. and L.-S. Chang, Presenter. 1992. Production of Large Quantity of Growth Regulatory Proteins, RB, p53, YY1, and pol , in Baculovirus-Insect Cell System. Presented at The 4th Annual DNA Viruses and Gene Expression Group-The Stone Laboratory Meeting. The Ohio State University. Columbus, OH.
Karacay, B., D.-Y. Lu, L. Zhu, and L.-S, Chang, Discussant. 1992. Regulation of the Human Erythrocyte Protein 4.2 Expression. The 4th Annual DNA Viruses and Gene Expression Group. Presented at The Stone Laboratory Meeting. The Ohio State University. Columbus, OH.
Karacay, B., D.-Y. Lu, L. Zhu, J.S. Lam, and L.-S. Chang, Presenter. 1992. Regulation of the Human Erythrocyte Protein 4.2 Expression. Presented at Thirteenth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Lu, D.-Y., and L.-S. Chang, Presenter. 1992. Transgenic Mouse Models for Studying the Function of the Retinoblastoma Susceptibility Gene During Development and Tumorigenesis. Presented at Thirteenth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Lu, D.-Y., L. Zhu, and L.-S. Chang, Presenter. 1992. Transgenic Mouse Models for Studying the Function of the Retinoblastoma Susceptibility Gene During Development and Tumorigenesis. The 4th Annual DNA Viruses and Gene Expression Group. Presented at The Stone Laboratory Meeting. The Ohio State University. Columbus, OH.
Zhu, L. and L.-S. Chang, Presenter. 1992. Construction and Biological Function of Putative RB Phosphorylation Mutants. Presented at Thirteenth Annual Children's Hospital and Children's Hospital Research Foundation Research Forum. Columbus, OH.
Chang, L.-S, Presenter. 1993. Transgenic Mice. Presented at Comprehensive Cancer Center Retreat. The Ohio State University. Columbus, OH.
Chang, L.-S., L. Zhu, and D.-Y. Lu, Presenter. 1993. Tumor Suppressor Genes, RB and p53, in Human Cancers. Presented at Ohio Symposium on Advances in Science and Technology. Columbus, OH.
Chen, M.-L., L. Zhao, and L.-S. Chang, Presenter. 1993. Genomic Structure of the Human DNA Polymerase Catalytic Subunit. Presented at The 5th Annual DNA Viruses and Gene Expression Group-The Stone Laboratory Meeting. The Ohio State University. Stone Lab, OH.
Tao, Y., R.-Y. Chuang, and L.-S. Chang, Presenter. 1993. Identification of YY1 Interacting Proteins. Presented at The 5th Annual DNA Viruses and Gene Expression Group-The Stone Laboratory Meeting. The Ohio State University. Stone Lab, OH.
Xie, E., L. Zhao, and L.-S. Chang, Presenter. 1993. Molecular Analyses of the Huamn Serotonin Receptor 5HT1c. Presented at The 5th Annual DNA Viruses and Gene Expression Group-The Stone Laboratory Meeting. The Ohio State University. Stone Lab, OH.
Karacay, B., D.-Y. Lu, L. Zhu, and L.-S. Chang, Presenter. 1994. Study of Regulation and Function of the Erythrocyte Membrane Protein: A Transgenic Approach. Presented at ICSABER Graduate Research Forum. The Ohio State University. Columbus, OH.
National
Akhmametyeva, E., Y. Wu, D.B. Welling, and L.-S. Chang., Presenter. 2002. Vestibular Schwannomas Express A Distinct Pattern of Alternatively Spliced NF2 Transcripts. Presented at Pediatric Academic Societies' Meeting. Baltimore, MD.
Chang, L.-S., E.M. Akhmametyeva, Y. Wu, and D.B. Welling, Presenter. 2002. Transcriptional and Posttranscriptional Regulation of the Human NF2 Gene. Presented at The NNFF International Consortium for Molecular Biology of NF1 and NF2. Aspen, CO.
Chang, L.-S., J.M. Lasak, E.M. Akhmametyeva, B. Gaheri, M. Salloum, and D.B. Welling, Presenter. 2002. cDNA Microarray Analysis of Vestibular Schwannomas. Presented at Pediatric Academic Societies' Meeting. Baltimore, MD.
Jiang, Y., W.D. Lo, E.M. Akhmametyeva, and L.-S. Chang, Presenter. 2002. Distinct Roles of E2F-1 and E2F-3 Transcription Factors in Regulating Neuronal Cell Death and Survival. Presented at Pediatric Academic Societies' Meeting. Baltimore, MD.
Lo, W.D., E. Akhmametyeva, and L.-S. Chang, Presenter. 2002. Modification of the N Terminal Portion of the Anti-apoptotic p35 Gene Attenuates Anti-caspase Activity in Neuronal Cells. Presented at Pediatric Academic Societies' Meeting. Baltimore, MD.
Yao, S. E.M. Akhmametyeva, D.B. Welling, And L.-S. Chang. 2002, Presenter. 2002. Analysis of Novel Alternatively Spliced NF2 Transcripts Expressed by Vestibular Schwannomas. Presented at Am. Neurotology Society Annual Meeting. , Desert Spring, CA.
Akhmametyeva, E., S. Yao, Y. Wu, D.B. Welling, and L.-S. Chang, Presenter. 2003. Novel Alternatively Spliced NF2 Transcripts In Vestibular Schwannomas. Presented at Pediatric Academic Societies' Meeting. Seattle, WA.
Chang, L.-S., E.M. Akhmametyeva, Y. Wu, and D.B. Welling, Presenter. 2003. Transcriptional Regulation of the Human Neurofibromatosis 2 (NF2) Gene. Presented at Pediatric Academic Societies' Meeting. Seattle, WA.
Lebedeva, L., S.A. Trunova, N.A. Bulgakova, L.V. Omelyanchuk, E.M. Akhmametyeva, and L.-S. Chang, Presenter. 2003. The Role of Drosophila merlin in the Control of Mitosis Exit and Development. Presented at The NNFF International Consortium for Molecular Biology of NF1 and NF2. Aspen, CO.
Lo, W.D., Y. Jiang, and L.-S. Chang, Presenter. 2003. Np73 Expression Is Associated with Neuronal Resistance to Oxygen-Glucose Deprivation. Presented at Pediatric Academic Societies' Meeting. Seattle, WA.
Welling, D.B., J.M. Lasak, E.M. Akhmametyeva, B.A. Neff, and L.-S. Chang, Presenter. 2003. Analysis of Genes and Pathways Deregulated in Vestibular Schwannomas. Presented at The NNFF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Yeager, N.D., R. Ewesuedo, F.B. Ruymann, and L.-S. Chang, Presenter. 2003. Topoisomerase I Activity in Pediatric Rhabdomyosarcoma. Presented at Pediatric Academic Societies' Meeting. Seattle, WA.
Akhmametyeva, E.M., D.B. Welling, and Chang, L.-S, Presenter. 2004. Expression of the Neurofibromatosis 2 Gene During Early Development. Presented at Pediatric Academic Societies' Annual Meeting. San Francisco, CA.
Chang, L.-S., E.M. Akhmametyeva, L. Lebedeva, N.A. Bulgakova, and L.V. Omelyanchuk, Presenter. 2004. Developmental Expression of the NF2 Gene and Genetic Analysis of Merlin Function. Presented at The NNFF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Chang, L.-S., L. Zhu, S. Weisbrode, C. Boesel, Presenter. 2004. Establishment of a Transgenic Osteosarcoma Mouse Model Using the Human Retinoblastoma Promoter-Driven SV40 T Antigen Gene. Presented at Pediatric Academic Societies' Annual Meeting. San Francisco, CA.
Lo, W.D., Y. Jiang, E.M. Akhmametyeva, and L.-S. Chang, Presenter. 2004. Transcription Factor E2F3a Promotes Neuronal Cell Survival Through the Induction of TrkA and Activation of the MAPK/ERK Pathway. Presented at Pediatric Academic Societies' Annual Meeting. San Francisco, CA.
Lorenz, M., B.A. Neff, E.M. Akhmametyeva, J. Rock, J. Shoreman, S. Tae, P. Schmalbrock, D.B. Welling, and L.-S. Chang, Presenter. 2004. Vestibular Schwannomas Xenografted in SCID Mice and Expression of Cyclin D1, D3, and Telomerase. Presented at The NNFF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Welling, D.B., BA. Neff, Brenda Hall, John M. Lasak, and L.-S. Chang, Presenter. 2004. Long-Term Hearing Rehabilitation in NF2 Patients With Cochlear Implants. Presented at The NNFF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Welling, D.B., J.M. Lasak, E.M. Akhmametyeva, B.A. Neff, and L.-S. Chang, Presenter. 2004. Analysis of Genes and Pathways Deregulated in Vestibular Schwannomas. Presented at The International Vestibular Schwannoma Meeting. Cambridge, England.
Akhmametyeva, E.M., H. Luo, M. Mihaylova, and L.-S. Chang, Presenter. 2005. Developmental Expression of the Neurofibromatosis 2 Gene Promoter in Transgenic Mice. Presented at Pediatric Academic Societies' Annual Meeting. Washington, D.C.
Akhmametyeva, E.M., H. Luo, M. Mihaylova, D.B. Welling, and L.-S. Chang, Presenter. 2005. The Neurofibromatosis Type 2 Gene Is Strongly Expressed in Neural Ectoderm and Pigmented Epithelium of the Retina During Early Development. Presented at The CTF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Chang, L.-S., M. Lorenz, J. Rock, E.M. Akhmametyeva, A. Jacob, G. Mihai, B.A. Neff, P. Schmalbrock, A.R. Chaudhury, and D.B. Welling, Presenter. 2005. Use of MRI for Non-Invasive Evaluation of Schwannoma Xenografts in SCID Mice. Presented at The CTF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Chang, L.-S., M. Lorenz, J. Rock, E.M. Akhmametyeva, B.A. Neff, P. Schmalbrock, A.R. Chaudhury, and D.B. Welling, Presenter. 2005. Growth Measurement of Vestibular Schwannoma Xenografts in SCID Mice. Presented at Pediatric Academic Societies' Annual Meeting. Washington, D.C.
Lo, W.D., Y. Jiang, E. Akhmametyeva, and L.-S. Chang, Presenter. 2005. Over-expression of p73 Results in Apoptotic Death of Postmitotic hNT Neurons. Presented at Pediatric Academic Societies' Annual Meeting. Washington, DC.
Neff, B.A., E. Oberstien, M. Lorenz,, A. Chadhury, D.B. Welling, and L.-S. Chang, Presenter. 2005. Cyclin D1 and D3 Expression in Vestibular Schwannomas. Presented at The COSM American Neurotology Society Meeting. Boca Raton, FL.
Omelyanchuk, L.V., N.V. Dorogova, S. Kopyl, E.M. Akhmameteva, J. Perceva, R.G. Fehon, and L.-S. Chang., Presenter. 2005. The Role of Merlin in Drosophila Spermatogenesis. Presented at The CTF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Welling, J.D., M. Lorenz, J. Rock, K.L. O'Neill, B.K. Murray, E. Akhmametyeva, D.B. Welling, and L.-S. Chang, Presenter. 2005. Development of a novel human vestibular schwannoma xenograft model in SCID mice. Presented at The American Association for Cancer Research Annual Meeting. Anaheim, CA.
Chang, L.-S., A. Jacob, M. Lorenz, J. Rock, E.M. Akhmametyeva, G. Mihai, B.A. Neff, P. Schmalbrock, E. Dodson, and D.B. Welling, Presenter. 2006. Magnetic Resonance Imaging Quantifies Schwannoma Xenografts in Immunocompromised Mice. Presented at Annual Triological Society Meeting. San Diego, CA.
Chang, L.-S., A. Jacob, M. Lorenz, J. Rock, E.M. Akhmametyeva, G. Mihai, P. Schmalbrock, Abhik R. Chaudhury, R. Lopez, J. Yamate, M.R. John, H. Wickert, B.A. Neff, E. Dodson, and D.B. Welling, Presenter. 2006. Magnetic Resonance Imaging Noninvasively Quantifies Schwannoma Xenografts in SCID Mice. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Aspen, CO.
Golovnina, K., A. Blinov, E.M. Akhmametyeva, L.V. Omelyanchuk, and L.-S. Chang, Presenter. 2006. Evolution and Origin of Merlin, the Product of the Neurofibromatosis Type 2 Tumor-Suppressor Gene. Presented at The CTF International Consortium for Molecular Biology of NF1 And NF2. Aspen, CO.
Omelyanchuk, L.V, N.V. Dorogova, S. Kopyl, E.M. Akhmameteva, R.G. Fehon, and Long-Sheng Chang, Presenter. 2006. The Role of Merlin in Drosophila Spermatogenesis and Wg Morphogen Trafficking in the Imaginal Disc. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Aspen, CO.
Welling, D. B., A. Jacob, M. Lorenz, J. Rock, E.M. Akhmametyeva, G. Mihai, B.A. Neff, P. Schmalbrock, L.-S. Chang, Presenter. 2006. Magnetic Resonance Imaging Noninvasively Quantifies Schwannoma Xenografts in SCID Mice. Presented at Barriers and Solutions in the Use of Mouse Models to Develop Therapeutic Strategies for NF1 and NF2-Associated Tumors: A Banbury Workshop. Cold Spring Harbor Laboratory. Long Island, NY.
Akhmametyeva, E.M., C.-Y. Kuan, M. Giovannini, D.B. Welling, and L.-S. Chang, Presenter. 2007. Merlin, the Product of the Neurofibromatosis 2 (NF2) Gene, Is Important for Neural Tube Closure, Neural Crest Cell Adhesion and Migration, and Brain Development. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Park City, UT.
Akhmametyeva, E.M., M. Mihaylova, H. Luo, D.B. Welling, and L.-S. Chang, Presenter. 2007. Regulation of the NF2 Gene Promoter Expression During Embryonic Development. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Aspen, CO.
Dorogova, N. E.M. Akhmametyeva, S. Kopyl, T. Dubatolova, R. Fehon, L.V. Omelyanchuk, and L.-S. Chang, Presenter. 2007. Tumor-Suppressor Merlin Regulates Epidermal Growth Factor Receptor Signaling in the Drosophila Wing through the Clathrin Adaptor Protein LAP. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Park City, UT.
Dorogova, N.V., E.M. Akhmameteva, S. Kopyl, N. Gubanova, R.G. Fehon, L.V. Omelyanchuk, and L.-S. Chang, Presenter. 2007. The Role of Merlin in Drosophila Spermatogenesis. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Park City, UT.
Jacob, A., T. Lee, E. Akhmametyeva, D.B. Welling, and L.-S. Chang, Presenter. 2007. Activation of the AKT Pathway in Human Vestibular Schwannomas. Presented at COSM, Am. Neurotology Society Annual Meeting. San Diego, CA.
Lee, T., A. Jacob, M. Packer, C.-S. Chen, D.B. Welling, and L.-S. Chang, Presenter. 2007. OSU03012 and (S)-HDAC-42, Two Novel Inhibitors of the PI3K/AKT Pathway, Are Potential Therapeutic Agents for Vestibular Schwannomas. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Park City, UT.
Packer, M., E.M. Akhmametyeva, L.-S. Chang, and D.B. Welling, Presenter. 2007. An Unusually Large, Recurrent Vestibular Schwannoma. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Park City, UT.
) Lee, T.X., M. Packer, E.M. Akhmametyeva, J. Huang, A. Jacob, S.K. Kulp, C.-S. Chen, D.B. Welling, and L.-S. Chang, Presenter. 2008. OSU03012, A Novel Inhibitor of The Pi3k/Akt Pathway, Is A Potential Therapeutic Agent For Vestibular Schwannomas and Malignant Schwannomas. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Bonita Springs, FL.
Akhmametyeva, E.M., C.-Y. Kuan, M. Giovannini, D.B. Welling, and L.-S. Chang, Presenter. 2008. Merlin Is Important for Neural Tube Closure, Neural Progenitor Cell Adhesion and Cerebral Cortex Development. Presented at The CTF International Consortium for Molecular Biology of NF1 and NF2. Bonita Springs, FL.
Packer, M.D., E.M. Akhmameteyva, J. Huang, D. Welling, and L.-S. Chang, Presenter. 2008. Biological progression of a rapidly growing recurrent vestibular schwannoma. Presented at The 54th Annual Air Force Clinical Surgeons Meeting. Cincinnati, OH.
Packer, M.D., E.M. Akhmameteyva, J. Huang, D.B. Welling, L.-S. Chang, Presenter. 2008. Biological progression of a rapidly growing recurrent vestibular schwannoma. Presented at The 7th International Conference on Head & Neck Cancer, Am. Head and Neck Society. San Francisco, CA.
Packer, M.D., T.X. Lee, S. Kulp, C.S. Chen, A. Jacob, D.B. Welling, L.-S. Chang, Presenter. 2008. Inhibition of the PI3 Kinase/AKT Pathway as a Treatment Strategy for Human Malignant Schwannoma and Vestibular Schwannoma. Presented at The 7th International Conference on Head & Neck Cancer, Am. Head and Neck Society. San Francisco, CA.
Packer, M.D., T.X. Lee, S. Kulp, C.S. Chen, A. Jacob, D.B. Welling, L.-S. Chang, Presenter. 2008. Inhibition of the PI3 Kinase/AKT Pathway as a Treatment Strategy for Human Malignant Schwannoma and Vestibular Schwannoma. Presented at The 54th Annual Air Force Clinical Surgeons Meeting. Cincinnati, OH.
Professional Activities
Research
| 1991 - 1996 | Internal Research Grants, Children's Hospital Research Foundation. Grant Reviewer. |
| 1994 | Internal Grant, Department of Pathology, The Ohio State University. Grant Reviewer. |
| 1994 | Interdisciplinary University Seed Grant, The Ohio State University. Grant Reviewer. |
| 1994 - 1998 | Oncology Training Grant Reviewing Committee, Division of Hematology-Oncology, Department of Internal Medicine, The Ohio State University College of Medicine. Grant Reviewer. |
| 1995 | Reviewer for Comprehensive Cancer Center Interactive Grants, The Ohio State University Comprehensive Cancer Center. Grant Reviewer. |
| 1996 | Comprehensive Cancer Center Grants, The Ohio State University Comprehensive Cancer Center. Grant Reviewer. |
| 1996 | Seed Grants, The Ohio State University. Grant Reviewer. |
| 1997 | Interdisciplinary Collaborative Grants, The Ohio State University Comprehensive Cancer Center. Grant Reviewer. |
| 1997 | University Seed Grants, The Ohio State University. Grant Reviewer. |
| 1997 | American Cancer Society Starter Grants, The Ohio State University Comprehensive Cancer Center. Grant Reviewer. |
| 1997 | Internal Grant, Department of Pathology, The Ohio State University. Grant Reviewer. |
| 1997 | Foundation Grants, New York, NY. Grant Reviewer. |
| 1998 - present | for Oncology Training Grant, Department of Internal Medicine, The Ohio State University School of Medicine & Public Health. Grant Reviewer. |
| 1998 | University Seed Grants, The Ohio State University. Grant Reviewer. |
| 1998 - 1999 | Comprehensive Cancer Center Grant, The Ohio State University Comprehensive Cancer Center. Grant Reviewer. |
| 2000 - 2002 | Internal Research Grants, Children's Research Institute, Columbus, OH. Grant Reviewer. |
| 2001 | Comprehensive Cancer Center Grants, The Ohio State University Comprehensive Cancer Center. Grant Reviewer. |
| 2008 | Medical Research Council, UK. Grant Reviewer. Key achievements: Referee |
Research Interests
Neurofibromatosis Type 2, Vestibular Schwannoma, and Schwannomatosis
Neurofibromatosis Type 1 and Tumor Microenvironment
Regulation and Function of the Retinoblastoma-Family Suppressor Genes
Neural-Specific Expression of the Serotonin 5-HT2C Receptor
Regulation of DNA Polymerase δ by RNA Editing
Traumatic Brain Injury
Undergrad., Grad. and Prof. Courses Taught
New Jersey College of Medicine & Dentistry, Dental Microbiology Laboratory
Princeton University, Department of Molecular Biology. Reading in Molecular Biology- A Tutorial Course for Junior Independent Paper
1983. New Jersey College of Medicine & Dentistry, Medical Microbiology Laboratory
Autumn 1999. The Ohio State University, BIOCHEMISTRY PROGRAM. Research in Biochemistry 999.01. 10 credit hours
Winter 2000. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Spring 2000. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Summer 2000. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Autumn 2000. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Winter 2001. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Spring 2001. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Summer 2001. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Autumn 2001. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Winter 2002. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Spring 2002. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Summer 2002. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Winter 2003. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Spring 2003. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Summer 2003. The Ohio State University, PATHOLOGY. Research in Pathology 999. 10 credit hours
Winter 2004. The Ohio State University, BIOCHEMISTRY PROGRAM. Individual Studies 793. 2 credit hours
Spring 2004. The Ohio State University, BIOCHEMISTRY PROGRAM. Individual Studies 793. 3 credit hours
Spring 2004. The Ohio State University, BIOCHEMISTRY PROGRAM. Individual Studies 793. 2 credit hours
Summer 2004. The Ohio State University, BIOCHEMISTRY PROGRAM. Research in Biochemistry 999.01. 15 credit hours
Summer 2004. The Ohio State University, MOLECULAR AND CELLULAR BIOCHEMISTRY. Individual Studies 793. 5 credit hours
Summer 2004. The Ohio State University, BIOCHEMISTRY PROGRAM. Research in Biochemistry 999.01. 12 credit hours
Summer 2005. The Ohio State University, INTEGRATED BIOMEDICAL SCIENCE. Individual Studies in Integrated Biomedical Science 793. 1 credit hours
Winter 2007. The Ohio State University, MOLECULAR,CELLULAR,AND DEVELOPMENTAL BIOLOGY. Individual Studies 693. 2 credit hours
Spring 2007. The Ohio State University, BIOCHEMISTRY PROGRAM. Individual Studies 793. 4 credit hours
Spring 2007. The Ohio State University, BIOCHEMISTRY PROGRAM. Individual Studies 793. 2 credit hours
