Brad Welling, MD, PhD
Previous Grants of Dr. Welling's
Abraham Jacob, MD
Long-Sheng Chang, PhD
Previous grants of Dr. Chang's
Phenotypic Determinants of Vestibular Schwannomas
The goal of this project is to examine the role of regulatory regions in the NF2 gene in schwannomas and further identify and understand factors which affect phenotypic expression in vestibular schwannomas.
Brad Welling, MD, PhD
05/10/05-04/30/10
NIH /R01DC005985
Phenotypic Determinants of Vestibular Schwannomas-Supplement
The goal of this project is to examine the role of regulatory regions in the NF2 gene in schwannomas and further identify and understand factors which affect phenotypic expression in vestibular schwannomas.
Brad Welling, MD, PhD
06/01/09-05/31/10
NIH /R01DC005985-05S1
Combination EGFR and AKT Pathway Inhibition for Treating Vestibular Schwannomas
Abraham Jacob, MD
08/15/08-08/14/09
Triological Society
Merlin Generation of a Mouse Model for Schwannomatosis
Long-Sheng Chang, MD
2009-2011
Department of Defense, USAMRMC
Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma.
Vestibular schwannomas (VS), brain tumors arising from the balance nerve, are one of the few deadly diseases of the ear, and patients with VS are currently treated with high risk modalities such as surgery and/or radiation therapy because no effective drugs are available. Our proposal seeks to study OSU-03012, a new drug that may revolutionize the treatment of VS. We plan to better understand how OSU-03012 inhibits VS tumor growth and profile its safety/efficacy parameters in order to transition this drug into human clinical trials.
Abraham Jacob, MD
8/1/2009-8/1/2014
1K08DC009644-01A1
