Dr. Jacob's OSU:pro Profile

Current OSU Appointment

Assistant Professor, Otolaryngology

Certifications

USMLE Steps 1,2 and 3: Federation of State Medical Boards

USMLE Steps 1,2 and 3: National Board of Medical Examiners

2005 - present

Board Certified: Otolaryngology Head and Neck Surgery, American Academy of Otolaryngology - Head and Neck Surgery

Chapters In Books

Haughey B and Jacob A. 2005. Otolaryngology. In The Washington Manual of Surgery 3rd Edition. Edited by Klinginsmith, M.E., et al Eds. Philadelphia: Lippincott Williams and Wilkins.

Jacob A and Welling DB. 2005. Evaluation of the Cranial Nerves. In Clinical Otology. 3rd edition. Edited by Gordon B. Hughes and Miles L. Pensak editors. New York: Thieme Medical Publishers.

Chole RA, Brody HA, and Jacob A. 2006. Surgery of the Mastoid and Petrosa. In Head and Neck Surgery – Otolaryngology. 4th Edition. Edited by Lippincott Williams and Wilkins. Philadelphia: Lippincott Williams and Wilkins.

Degrees

1994	B.S., University of Michigan, Biomedical Science

1997	M.D., University of Michigan, Medicine

Editorial Activities

Ad Hoc Reviewer

Laryngoscope.

Otology & Neurotology.

Journal of Neurology.

Fellowship, Internship or Residency

1997 - 1998

Internship, General Surgery, Washington University School of Medicine, St. Louis, MO, United States.

1998 - 2004

Residency, Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, United States.

1999 - 2001

Physician Scientist Training Program, Basic Science Research, Washington University School of Medicine, St. Louis, MO, United States.

07/04 - 06/06

Fellowship, Otology/Neurotology, The Ohio State University College of Medicine, Department of Otolaryngology, Columbus, OH, United States.

Honors

Phi Beta Kappa Honor Society. University of Michigan, Ann Arbor, MI, United States. Subject: Academic Excellence

Phi Kappa Phi Honor Society. University of Michigan, Ann Arbor, MI, United States. Subject: Academic Excellence

Alpha Omega Alpha Honor Society. University of Michigan, Ann Arbor, MI, United States. Subject: Academic Excellence in Medical School

James B. Angell Scholar. University of Michigan, Ann Arbor, MI, United States. Subject: Academic Excellence

Alpha Omega Alpha. University of Michigan, Ann Arbor, MI, United States.

Golden Key National Honor Society. University of Michigan, Ann Arbor, MI, United States.

1990 - 1994

Academic Honor Roll - Dean's List. University of Michigan, Ann Arbor, MI, United States. Subject: Undergraduate Studies; Academic Excellence

2007	Guide to America’s Top Physicians. Consumers’ Research Council of America.

2007	Winner, Forty Under 40 award. Columbus Business First. Subject: Recognizing 40 people in the Central Ohio business world under age 40 who show professional drive and remain active in their communities.

2007	Nicholas Torok Award. American Neurotology Society. Subject: Pathogenesis of Vestibular Schwannomas

2008 - 2009

Triological Society Career Development Award. Triological Society. Subject: Development of Novel Treatments for Vestibular Schwannomas

Languages

English: (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)

Licensure

State Medical License: State of Ohio

1999 - 2006

State Medical License Missouri-Inactive: State of Missouri

Memberships

2002 - present

Member. American Medical Association

2002 - present

Member. American Neurotology Society

2002 - present

Member. Association for Research in Otolaryngology

2002 - present

Member. Ohio State Medical Association

2002 - present

Member. Triological Society

2002 - present

Member. American Academy of Otolaryngology – Head & Neck Surgery

Peer Reviewed Journal Articles

Sisk, E, A; Bradford, C, R; Jacob, A; Yian, C, H; Staton, K, M; Tang, G; Harris, M, O; Carey, T, E; Lancaster, W, D; Gregoire, L. 2000. Human papillomavirus infection in "young" versus "old" patients with squamous cell carcinoma of the head and neck. Head & neck. Vol. 22, no. 7: 649-57.

Jacob, A; Faddis, B, T; Chole, R A. 2001. Chronic bacterial rhinosinusitis: description of a mouse model. Archives of otolaryngology--head & neck surgery. Vol. 127, no. 6: 657-64.

Jacob, Abraham; Faddis, Brian, T; Chole, Richard A. 2002. MeroGel hyaluronic acid sinonasal implants: osteogenic implications. The Laryngoscope. Vol. 112, no. 1: 37-42.

Chang LS, Akhmametyeva EM, Mihaylova M, Luo H, Tae S, NeffBA, Jacob A, Welling DB. 2005. Dissecting the molecular pathways in vestibular schwannoma tumorigenesis. Rescent Research in Development in Genes and Genomes. Vol. 1.

Goebel, Joel, A; Jacob, Abraham. 2005. Use of Mimix hydroxyapatite bone cement for difficult ossicular reconstruction. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. Vol. 132, no. 5: 727-34.

Husein OF, Jacob A, Massick DD, Welling, DB. 2005. Recurrent Multiple Myeloma of the Skull Base: Case Report and Review of the Literature. ENT Journal.

Jacob A and Welling DB. 2005. cerebellopontine angle metastatic melanoma: A case report. ENT Journal.

Jacob, Abraham; Kneile, Jeffrey; Welling, D Bradley. 2005. Angiofibrolipoma of the ear canal. The Laryngoscope. Vol. 115, no. 8: 1461-2.

Goebel JA; Jacob A. 2005. Use of Mimix hydroxyapatite bone cement for difficult ossicular reconstruction.  Otolaryngology--Head And Neck Surgery: Official Journal Of American Academy Of Otolaryngology-Head And Neck Surgery. Vol. 132, no. 5. (May 1): 727.

Jacob, Abraham; Morris, Targhee, J; Welling, D Bradley. 2006. Leaving a lasting impression: ear mold impressions as middle ear foreign bodies. The Annals of otology, rhinology, and laryngology. Vol. 115, no. 12: 912-6.

Jacob A; Chole RA. 2006. Survey anatomy of the paranasal sinuses in the normal mouse.  The Laryngoscope. Vol. 116, no. 4. (April 1): 558.

Chang LS; Jacob A; Lorenz M; Rock J; Akhmametyeva EM; Mihai G; Schmalbrock P; Chaudhury AR; Lopez R; Yamate J; John MR; Wickert H; Neff BA; Dodson E; Welling DB. 2006. Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency mice.  The Laryngoscope. Vol. 116, no. 11. (November 1): 2018.

Jacob, Abraham; Bortman, Jared, S; Robinson, Lawrence L Jr; Yu, Lianbo; Dodson, Edward, E; Welling, D Bradley. 2007. Does packing the eustachian tube impact cerebrospinal fluid rhinorrhea rates in translabyrinthine vestibular schwannoma resections?. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Vol. 28, no. 7. (IF: 1.339)

Jacob, Abraham; Brightman, Rebecca, P; Welling, D Bradley. 2007. Bilateral cerebellopontine angle metastatic melanoma: a case report. Ear, nose, & throat journal. Vol. 86, no. 7.

Otto, Bradley, A; Jacob, Abraham; Klein, Michael, J; Welling, D Bradley. 2007. Chondromyxoid fibroma of the temporal bone: case report and review of the literature. The Annals of otology, rhinology, and laryngology. Vol. 116, no. 12. (IF: 1.096)

Husein OF; Jacob A; Massick DD; Welling DB. 2007. Recurrence of isolated multiple myeloma in the skull base: a case report and review of the literature.  Ear, Nose, & Throat Journal. Vol. 86, no. 9. (September 1): 555.

Jacob A; Robinson LL Jr; Bortman JS; Yu L; Dodson EE; Welling DB. 2007. Nerve of origin, tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma resections at a tertiary care academic center.  The Laryngoscope. Vol. 117, no. 12. (December 1): 2087.

Jacob A; Lee TX; Neff BA; Miller S; Welling B; Chang LS. 2008. Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology. Vol. 29, no. 1. (January 1): 58. (IF: 1.410)

Jatana KR; Jacob A; Slone HW; Ray-Chaudhury A; Welling DB. 2008. Spinal myxopapillary ependymoma metastatic to bilateral internal auditory canals.  The Annals Of Otology, Rhinology, And Laryngology. Vol. 117, no. 2. (February 1): 98.

Lee TX; Packer MD; Huang J; Akhmametyeva EM; Kulp SK; Chen CS; Giovannini M; Jacob A; Welling DB; Chang LS. 2009. Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. European Journal Of Cancer (Oxford, England: 1990). Vol. 45, no. 9. (June 1): 1709.

Evans DG; Kalamarides M; Hunter-Schaedle K; Blakeley J; Allen J; Babovic-Vuskanovic D; Belzberg A; Bollag G; Chen R; DiTomaso E; Golfinos J; Harris G; Jacob A; Kalpana G; Karajannis M; Korf B; Kurzrock R; Law M; McClatchey A; Packer R; Roehm P; Rubenstein A; Slattery W 3rd; Tonsgard JH; Welling DB; Widemann B; Yohay K; Giovannini M. 2009. Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.  Clinical Cancer Research: An Official Journal Of The American Association For Cancer Research. Vol. 15, no. 16. (August 15): 5032.

Positions

2006 - present

Assistant Professor, The Ohio State University, The Ohio State University, Otolaryngology. Columbus, OH, United States.

Presentations

Invited Presentations

Local

Abraham Jacob, Presenter. 2009. Baha: Osteointegrating Hearing Prosthesis. Presented at Cochlear Americas Hearing Aid Seminar. Columbus, OH. (May 13)

Regional

Abraham Jacob, MD, Presenter. 2003. Sinonasal Inflammation in the Murine Model. Presented at Otolaryngology Grand Rounds, UCSF Medical Center. (February)

Abraham Jacob, MD, Presenter. 2005. Human Vestibular Schwannoma: Developing an Animal Model. Presented at Otolaryngology Grand Rounds, The University of Utah Health Sciences Center. Salt Lake City, UT. (August 1)

Abraham Jacob, MD, Presenter. 2005. Human Vestibular Schwannoma: Developing an Animal Model. Presented at Otolaryngology Grand Rounds, The University of Minnesota. Twin Cities, MN. (September 1)

Dr Abraham Jacob, Presenter. 2005. Use of Mimix™ Hydroxyapatite Bone Cement for Difficult Ossicular Chain Reconstruction. Presented at Otology Conference, The University of Minnesota. Twins City, MN. (September 1)

Abraham Jacob, MD, Presenter. 2005. Human Vestibular Schwannoma: Developing an Animal Model. Presented at Otolaryngology Grand Rounds, The University of Mississippi. Jackson, MS. (October 1)

Abraham Jacob, MD, Presenter. 2007. "Tumors of the Lateral Skull Base and Cerebellopontine Angle: A Neurotologist's Perspective". Presented at Holzer Medical Center Grand Rounds. Gallipolis, OH. (January 5)

Abraham Jacob, MD, Presenter. 2007. "Chronic Otitis Media With and Without Cholesteatoma". Presented at Scioto County Medical Society Grand Rounds. OH. (February 23)

Abraham Jacob, MD, Presenter. 2007. Vertigo and the Vestibular System. Presented at Grand Rounds MedCentral Health System. Mansfield, OH. (October 17)

Abraham Jacob, MD, Presenter. 2008. Idiopathic Sudden Sensorineural Hearing Loss. Presented at Grand Rounds, Genesis Health System. Zanesville, OH. (March 4)

National

(Long-Sheng Chang, Mark Lorenz, Jonathan Rock, Elena M. Akhmametyeva, Abraham Jacob, Brian A. Neff, Petra Schmalbrock, Abhik R. Chaudhury, and D. Bradley Welling), Poster Presenter. 2005. Growth Measurement of Vestibular Schwannoma Xenografts in SCID Mice Using Magnetic Resonance Imaging (MRI). Presented at CTF International Consortium for the Molecular Biology of NF1, NF2, and Schwannomatosis. (June)

(Long-Sheng Chang, Abraham Jacob, Mark Lorenz, Jonathan Rock, Elena M. Akhmametyeva, Georgeta Mihai, Brian A. Neff, Petra Schmalbrock, Jyoyi Yamate, Markus R. John, Hannes Wickert, Edward Dodson, and D. Bradley Welling), Poster Presenter. 2006. Magnetic Resonance Imaging Non-invasively quantifies schwannoma xenografts in SCID Mice. Presented at Children's Tumor Foundation Neurofibromatosis Meeting. Aspen, CO. (June)

(Tina Lee, Abraham Jacob, Mark Packer, Chin-Shih Chen, D. Bradley Welling and Long-Sheng Chang), Poster Presenter. 2007. OSU03012 and (S)-HDAC-42, Two Novel Inhibitors of the PI3K/AKT Pathway, Are Potential Therapeutic Agents for Vestibular Schwannomas. Presented at Children's Tumor Foundation Neurofibromatosis Meeting. Park City, UT. (June)

Abraham Jacob, MD, Presenter. 2008. Preclinical Drug Development: The Ohio State University and The Research Institute at Nationwide Children's Hospital. Presented at Children's Tumor Foundation Podium Presentation. Park City, UT. (June)

Janet Oblinger, Tina Lee, Mark Packer, Jie Huang, Elena Akhmametyeva, Matthew Bush, Samuel Kulp, Ching-Shih Chen, Marco Giovannini, D. Bradley Welling, Long-Sheng Chang, Abraham Jacob, Poster Presenter. 2009. OSU-03012 and HDAC-42: Novel Small Molecule Inhibitors of the AKT Pathway for the Treatment of Vestibular Schwannoma and Malignant Schwannoma. Presented at Children's Tumor Foundation Neurofibromatosis Meeting. Portland, OR. (April 2)

Matthew Bush, Janet Oblinger, Sarah Burns, Samuel Kulp, Ching-Shih Chen, Volker Senner, Abraham Jacob, D. Bradley Welling, Long-Sheng Chang, Poster Presenter. 2009. Preclinical Evaluation of HDAC Inhibitors and an EGFR Inhibitor on Human Vestibular Schwannoma and Meningioma. Presented at Children's Tumor Foundation Neurofibromatosis Meeting. Portland, OR. (June)

Other Presentations

Local

Abraham Jacob, MD, Presenter. 2000. Chronic Bacterial Rhinosinusitis: Developing a Mouse Model. Presented at Joseph Ogura Research Forum, Washington University School of Medicine. St. Louis.

Abraham Jacob, MD, Presenter. 2001. Merogel® Sinonasal Implants: Osteogenic Potential? Presented at Joseph Ogura Research Forum, Washington University School of Medicine. St. Louis.

Abraham Jacob, MD, Presenter. 2002. The Normal Survey Anatomy of the Mouse Paranasal Sinuses. Presented at Joseph Ogura Research Forum, Washington University School of Medicine. St. Louis.

(Long-Sheng Chang, Mark Lorenz, Jonathan Rock, Elena M. Akhmametyeva, Abraham Jacob, Brian A. Neff, Petra Schmalbrock, Abhik R. Chaudhury, and D. Bradley Welling), Poster Presenter. 2005. "Growth Measurement of Vestibular Schwannoma Xenografts in SCID Mice Using Magnetic Resonance Imaging (MRI)". Presented at Comprehensive Cancer Center Meeting, The Ohio State University Medical Center. Columbus, OH. (March)

Abraham Jacob, MD, Presenter. 2005. Use of MRI for Non-Invasive Evaluation of Schwannoma Xenografts in SCID Mice: A Pilot Study. Presented at The Ohio State University Dept. of Radiology, High Field MRI Symposium, to The Ohio State University Department of Radiology. Columbus. (March)

Abraham Jacob, MD, Presenter. 2005. Human Vestibular Schwannoma: Developing an Animal Model. Presented at Thirteenth Annual Department of Otolaryngology William H. Saunders Symposium. Columbus, OH. (June)

Abraham Jacob, MD, Presenter. 2006. Use of Mimix™ Hydroxyapatite Bone Cement for Difficult Ossicular Chain Reconstruction. Presented at Fourteenth Annual Department of Otolaryngology William H. Saunders Symposium. Columbus, OH. (June 1)

Abraham Jacob, MD, Presenter. 2007. "Current Management Strategies for Sudden Hearing Loss. Presented at Current Management Strategies in Otolaryngology for the Primary Care Specialist. (May 19)

Tina X. Lee, Mark Packer, Elena M. Akhmametyeva, Jie Huang, Abraham Jacob, Samuel K. Kulp, Ching-Shih Chen, D. Bradley Welling, and Long-Sheng Chang, Poster Presenter. 2008. Growth Inhibitory and Anti-Tumor Activities of OSU-03012, a Novel PDK1 Inhibitor, on Vestibular Schwannoma and Malignant Schwannoma Cells. Presented at OSU Comprehensive Cancer Center Research Day. Columbus, OH. (March)

Janet Oblinger, Long-Sheng Chang, D. Bradley Welling, Abraham Jacob, Poster Presenter. 2009. The Effects of OSU-03012 on th Cell Cycle and the Expression of Key Cell Cycle Regulatory Proteins. Presented at 8th Annual OSUMC Research Day. Columbus, OH. (April 2)

Justin Wheeler, Janet Oblinger, Matthew Bush, Samuel Kulp, Ching-Shih Chen, D. Bradley Welling, Long-Sheng Chang, Abraham Jacob, Poster Presenter. 2009. Efficacy of HDAC and Radiation Combination Therapy on Human Schwannoma Tumor Cells. Presented at 8th Annual OSUMC Research Day. Columbus, OH. (April 2)

Matthew Bush, Sarah Burns, Samuel Kulp, Ching-Shih Chen, Abraham Jacob, D. Bradley Welling, Long-Sheng Chang, Poster Presenter. 2009. Mutation Analysis and In Vitro HDAC Inhibitor Treatment of Benign Human Meningioma Cells. Presented at 8th Annual OSUMC Research Day. Columbus, OH. (April 2)

National

Abraham Jacob, MD, Poster Presenter. 2001. "Chronic Sinusitis: A Mouse Model". Presented at Association for Research in Otolaryngology Mid-Winter Meeting. (February)

(Long-Sheng Chang, Abraham Jacob, Mark Lorenz, Jonathan Rock, Elena M. Akhmametyeva, Georgeta Mihai, Brian A. Neff, Petra Schmalbrock, Jyoyi Yamate, Markus R. John, Hannes Wickert, Edward Dodson, and D. Bradley Welling), Poster Presenter. 2006. Magnetic Resonance Imaging Non-Invasively Quantifies Schwannoma Xenografts in SCID Mice o Magnetic Resonance Imaging Non-invasively quantifies schwannoma xenografts in SCID Mice. Presented at Trilogic Middle/Western Section Meeting. San Diego, CA. (February)

(Jacob, A, Robinson LL, Bortman, JS, Yu L, Dodson EE, Welling DB), Poster Presenter. 2007. Nerve of Origin, Tumor Size, Hearing Preservation, and Facial Nerve Outcomes in 359 Vestibular Schwannoma Does Packing the Eustachian Tube Impact CSF Rhinorrhea Rates in Translabyrinthine Vestibular Schwannoma Resections? Presented at Trilogical Society Middle Section Meeting. Marco Island, FL.

(Rastatter J, Jacob A, Fettman NA, Kalan AS, Welling DB), Poster Presenter. 2007. Revision Stapedectomy: 2006 Update. Presented at Trilogical Society Middle Section Meeting. Marco Island, FL. (February)

Abraham Jacob, MD, Presenter. 2007. "PI3-kinase/AKT Pathway Activation in Human Vestibular Schwannoma". Presented at Nicholas Torok Vestibular Award Presentation at the American Neurotology Society Spring Meeting. Key West, FL. (April 27)

Justin Wheeler, Janet Oblinger, Matthew Bush, Samuel Kulp, Ching-Shih Chen, D. Bradley Welling, Long-Sheng Chang, Abraham Jacob, Presenter. 2009. HDAC-42 as a Potential Radiosensitizer for Human Schwannomas. Presented at American Academy of Otolaryngology - Head and Neck Surgery Foundation Annual Meeting. San Diego, CA. (October 6)

Matthew Bush, Janet Oblinger, Samuel Kulp, Ching-Shih Chen, Abraham Jacob, Long-Sheng Chang, D. Bradley Welling, Presenter. 2009. Novel Inhibitors of Vestibular Schwannomas and Meningiomas. Presented at American Academy of Otolaryngology - Head and Neck Surgery Foundation Annual Meeting. San Diego, CA. (October 6)

Professional Activities

Consultation

09/2008

Consultant - Otologic Drill Technologies. Industry. Medtronic. Medtronic ENT. Jacksonville, Florida, USA. Key achievements: Reviewed prototype otologic drill and provided engineers with key information regarding automated suction irrigation systems

10/2009

Consultant - Otologic Drill Technologies. Industry. Medtronic. Medtronic NT. Dallas, Texas, USA. Key achievements: Key feedback regarding existing and upcoming otologic drill technologies; surgical dissection on cadaver specimens

Radio and TV Shows

Expert Otologist. Aural Rehabilitation: Hearing Aids, Cochlear Implants, and BAHA. OSU MedBreak [TV.]. Channel 4 News. May 2007.

Expert Otologist. Factors predicting the response of melatonin on tinnitus [TV.]. Channel 10. May 2007.

Medical Professional. ONN story on tinnitus and ear care [TV.]. July 2007.

Research Interests

As an Otolaryngologist subspecializing in the practice of Otology, Neurotology, and Cranial Base Surgery, I am committed to improving the lives of people inflicted with hearing and balance disorders.

My research at OSU has focused on the pathogenesis and treatment of vestibular schwannomas (VS), intracranial, skull base neoplasms originating on the vestibulocochlear nerve. I have published two clinical retrospective reviews on patients treated surgically at OSU, looking at tumor nerve of origin, CSF leak rates, hearing preservation rates, facial nerve outcomes, etc. An IRB application is currently in preparation to collect this data prospectively. I have also published several case reports regarding related and unrelated skull base pathologies. My basic science work has focused on VS. In 2007/2008, I determined that the AKT intracellular signaling pathway is active in human vestibular schwannomas and that this pathway helps drive VS growth/proliferation (Torok Award, 2007 - Podium presentation @ The American Neurotology Society Meeting; published Otology & Neurotology 2008). Along with my collaborators, we then demonstrated that inhibiting the AKT pathway can suppress tumor growth both in cell culture and in animal models (this work was published in EJC 2009, the highest impact publication ever coming from the OSU NF2/VS research group). In August of 2009, I received an NIH/NIDCD K08 grant (5-years; $1.16 million) as Principal Investigator) to study AKT/OSU-03012 in greater detail. The Children's Tumor Foundation, the primary group leading the research effort against NF2-associated tumors such as VS, has provided me with a drug development grant (2007) and invited me to give a podium presentation regarding VS drug development efforts at OSU during their national meeting in 2008. In late 2007, I was invited to participate in an international consensus panel - establishing the goals and outcome measures for clinical trials targeting NF2-associated tumors.

Because other growth promoting pathways may also be relevant to pathogenesis (and therefore treatment) of vestibular schwannomas, I have recently helped establish a cross-discipline collaboration (Dr. CS Chen - medicinal chemistry/pharmacology, Dr. Kenneth Chan - expert in pharmacokinetics/pharmacodynamics at the OSU Comprehensive Cancer Center, and Dr. Matthew Ringel - Endochrinology/Thyroid Cancer) to look closely at the PAK signaling pathway in several human cancers and in NF2-associated tumors wuch as schwannomas. We have developed 18 novel small molecule inhibitors of the PAK kinase and are initiating biological screening assays to determine their potency and their specificity. In the future, lead agents will be identified and tested both in vitro and in vivo for efficacy, toxicity, etc.

A new initiative this year has been the James Care Hearing Conservation Program. Patients undergoing chemotherapy – particularly the platinum agents - lose substantial amounts of hearing due to treatment, and unfortunately, many are not adequately aware of chemotherapy-associated ototoxicity prior to initiating therapy. At The Ohio State University Medical Center, most of these patients are not screened for hearing loss before chemotherapy, and typically, they are not monitored for ongoing hearing loss during/after treatment. This compromises the informed consent process and creates significant long term, potentially preventable morbidity for cancer survivors. The immediate goals of The James-Care Hearing Conservation Program (JCHCP) are to standardize the hearing screening process at Ohio State for all patients undergoing conventional chemotherapy, provide these patients and their treating physicians with real-time data about drug-induced ototoxicity, and to establish a prospective database of chemotherapy-related hearing outcomes for future research. In the long term, the JCHCP may integrate into the existing Phase I/Phase II clinical trials program at The OSU Comprehensive Cancer Center – providing OSU CCC investigators with the means of assessing ototoxicity during administration of investigational drugs. In addition, this program can be used to determine the feasibility, safety, and efficacy of novel intratympanic (IT) treatments for chemotherapy-associated hearing loss as they become available.

Undergrad., Grad. and Prof. Courses Taught

2006. The Ohio State University College of Medicine, Medical School Curriculum. Med 3 Ambulatory Clerkship , 34% Taught

2007. The Ohio State University College of Medicine, Otolaryngology - Head & Neck Surgery. Temporal Bone Dissection Course , 25% Taught

2007. The Ohio State University College of Medicine, Medical School Curriculum. Med 3 Ambulatory Clerkship , 34% Taught

Spring 2007. The Ohio State University College of Medicine, Otolaryngology - Head & Neck Surgery. Resident Core Curriculum - Otology/Neurotology , 25% Taught

2008. The Ohio State University College of Medicine, Medical School Curriculum. Med 3 Ambulatory Clerkship , 34% Taught

Spring 2008. The Ohio State University College of Medicine, Medical School Curriculum. Med 1 Integrated Pathway - Neuroscience 662. , 5% Taught

Spring 2008. The Ohio State University College of Medicine, Otolaryngology - Head & Neck Surgery. Resident Temporal Bone Course , 25% Taught

Spring 2008. The Ohio State University College of Medicine, Otolaryngology - Head & Neck Surgery. Resident Core Curriculum - Otology/Neurotology , 25% Taught

2009. The Ohio State University College of Medicine, Medical School Curriculum. Med 3 Ambulatory Clerkship , 5% Taught

Spring 2009. The Ohio State University College of Medicine, Medical School Curriculum. Med 1 Integrated Pathway - Neuroscience 662. , 5% Taught

Spring 2009. The Ohio State University College of Medicine, Otolaryngology - Head & Neck Surgery. Resident Temporal Bone Course , 25% Taught

Spring 2009. The Ohio State University College of Medicine, Otolaryngology - Head & Neck Surgery. Resident Otology Core Curriculum