Dr. Pan's OSU:pro Profile

Current OSU Appointment

Associate Professor, Otolaryngology

Chapters In Books

1. Pan Q, Martell RE, O'Connell TD, and Simpson RU. 1997. 1,25-Dihydroxyvitamin D3 regulation of c-myc expression and MIE binding proteins during HL-60 cell differentiation. In Vitamin D. Chemical, Biochemical, and Clinical Update. Edited by A.W. Norman. Berlin: Walter DeGrueyler.

Degrees

B.S., Rensselaer Polytechnic Institute, Biology

1999	Ph.D., University of Michigan, pharmacology

Editorial Activities

Ad Hoc Reviewer

Cancer Research.

Clinical Cancer Research.

Breast Cancer Research and Treatment.

European Journal of Surgical Oncology.

Clinical and Experimental Metastasis.

Fellowship, Internship or Residency

1994 - 1999

Graduate Student Research Assistant, Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI, United States.

2000 - 2003

Postdoctoral Fellow, Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States.

Honors

2008 American Cancer Society Research Scholar.

2008 FAMRI Young Clinical Scientist Award.

2004 NIH/NCI Head and Neck SPORE Career Development Award.

2004 USAMRMC Breast Cancer Program Concept Award.

2002 USAMRMC Breast Cancer Program Postdoctoral Trainee Award.

2001 NIH T32 Cancer Biology Training Program Postdoctoral Fellowship.

2001 Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship.

2001 Central Society for Clinical Research Travel Award.

1997 Newton-Loeb/University of Michigan Comprehensive Cancer Center Predoctoral Fellowship.

1997 Young Investigator’s Travel Award for Vitamin D Conference.

1997 ASPET Predoctoral Travel Award.

1992 Rensselaer Undergraduate Research Award.

1992 National Dean’s List.

1991 National Institutes of Health Undergraduate Research Fellowship.

Memberships

Member. American Association for Cancer Research

Member. American Society for Pharmacology and Experimental Therapeutics

Peer Reviewed Journal Articles

Pan Q; Martell RE; O'Connell TD; Simpson RU. 1996. 1,25-Dihydroxyvitamin D3-regulated binding of nuclear proteins to a c-myc intron element. Endocrinology. Vol. 137, no. 10. (October 1): 4154.

Pan Q; Granger J; O'Connell TD; Somerman MJ; Simpson RU. 1997. Promotion of HL-60 cell differentiation by 1,25-dihydroxyvitamin D3 regulation of protein kinase C levels and activity. Biochemical Pharmacology. Vol. 54, no. 8. (October 15): 909.

Simpson RU; O'Connell TD; Pan Q; Newhouse J; Somerman MJ. 1998. Antisense oligonucleotides targeted against protein kinase Cbeta and CbetaII block 1,25-(OH)2D3-induced differentiation. The Journal Of Biological Chemistry. Vol. 273, no. 31. (July 31): 19587.

Pan Q; Simpson RU. 1999. c-myc intron element-binding proteins are required for 1, 25-dihydroxyvitamin D3 regulation of c-myc during HL-60 cell differentiation and the involvement of HOXB4. The Journal Of Biological Chemistry. Vol. 274, no. 13. (March 26): 8437.

Hullinger TG; Pan Q; Viswanathan HL; Somerman MJ. 2001. TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements. Experimental Cell Research. Vol. 262, no. 1. (January 1): 69.

Pan Q; Simpson RU. 2001. Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression. The Journal Of Endocrinology. Vol. 169, no. 1. (April 1): 153.

van Golen KL; Bao LW; Pan Q; Miller FR; Wu ZF; Merajver SD. 2002. Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. Clinical & Experimental Metastasis. Vol. 19, no. 4. (January 1): 301.

Kleer CG; Zhang Y; Pan Q; van Golen KL; Wu ZF; Livant D; Merajver SD. 2002. WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene. Vol. 21, no. 20. (May 9): 3172.

Pan Q; Kleer CG; van Golen KL; Irani J; Bottema KM; Bias C; De Carvalho M; Mesri EA; Robins DM; Dick RD; Brewer GJ; Merajver SD. 2002. Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer Research. Vol. 62, no. 17. (September 1): 4854.

Redman BG; Esper P; Pan Q; Dunn RL; Hussain HK; Chenevert T; Brewer GJ; Merajver SD. 2003. Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer. Clinical Cancer Research: An Official Journal Of The American Association For Cancer Research. Vol. 9, no. 5. (May 1): 1666.

Pan Q; Bao LW; Kleer CG; Brewer GJ; Merajver SD. 2003. Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma. Molecular Cancer Therapeutics. Vol. 2, no. 7. (July 1): 617.

Pan Q; Bao LW; Merajver SD. 2003. Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade. Molecular Cancer Research: MCR. Vol. 1, no. 10. (August 1): 701.

Kleer CG; Zhang Y; Pan Q; Gallagher G; Wu M; Wu ZF; Merajver SD. 2004. WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer. Breast Cancer Research: BCR. Vol. 6, no. 2. (January 1): R110.

Kleer CG; Zhang Y; Pan Q; Merajver SD. 2004. WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia (New York, N.Y.). Vol. 6, no. 2. (March 1): 179.

Marcus B; Arenberg D; Lee J; Kleer C; Chepeha DB; Schmalbach CE; Islam M; Paul S; Pan Q; Hanash S; Kuick R; Merajver SD; Teknos TN. 2004. Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma. Cancer. Vol. 101, no. 12. (December 15): 2779.

Teknos TN; Islam M; Arenberg DA; Pan Q; Carskadon SL; Abarbanell AM; Marcus B; Paul S; Vandenberg CD; Carron M; Nor JE; Merajver SD. 2005. The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck. Archives Of Otolaryngology--Head & Neck Surgery. Vol. 131, no. 3. (March 1): 204.

Pan Q; Bao LW; Kleer CG; Sabel MS; Griffith KA; Teknos TN; Merajver SD. 2005. Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Research. Vol. 65, no. 18. (September 15): 8366.

Kleer CG; Teknos TN; Islam M; Marcus B; Lee JS; Pan Q; Merajver SD. 2006. RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. Clinical Cancer Research: An Official Journal Of The American Association For Cancer Research. Vol. 12, no. 15. (August 1): 4485.

Pan Q; Bao LW; Teknos TN; Merajver SD. 2006. Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma. Cancer Research. Vol. 66, no. 19. (October 1): 9379.

Hassouneh B; Islam M; Nagel T; Pan Q; Merajver SD; Teknos TN. 2007. Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer. Molecular Cancer Therapeutics. Vol. 6, no. 3. (March 1): 1039.

Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JMG, Pan Q, Carey TE, Bradford CR, Prince ME, Cordell KG, Kirkwood KL, and D'Silva NJ. 2008. Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma. Cancer Research. Vol. 68: 3959-3969. (IF: 7.672)

Positions

1997	Teaching Assistant, University of Michigan, Nursing Pharmacology. Ann Arbor, MI, United States.

2003 - 2006

Research Investigator (research faculty), University of Michigan, Department of Internal Medicine, Division of Hematology and Oncology. Ann Arbor, MI, United States.

2007 - 2008

Assistant Professor, University of Michigan, Department of Otolaryngology,Division of Head and Neck Surgery. Ann Arbor, MI, United States.

2007 - 2008

Assistant Professor, University of Michigan, Department of Internal Medicine, Division of Hematology and Oncology. Ann Arbor, MI, United States.

2008 - present

Associate Professor, The Ohio State University Medical Center, Department of Otolaryngology-Head and Neck Surgery. Columbus, OH, United States.

2008 - present

Director, Head and Neck Oncology Research Program, The Ohio State University Medical Center, Department of Otolaryngology-Head and Neck Surgery. Columbus, OH, United States.

Undergrad., Grad. and Prof. Courses Taught

University of Michigan, Endocrine Pharmacology, Course: Nursing Pharmacology