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Basic Science Research

Home > Research > Basic Science Research

Basic research within the Department of Otolaryngology-Head and Neck Surgery focuses on head and neck oncology, NF2/vestibular schwannomas, and virtual temporal bone simulation.

The department has six faculty members whose mission is to promote basic and clinical research focused on diseases of the ear. Currently the six faculty members who comprise the group have been awarded four NIH grants and three grants from private foundations or industry totaling $3.3 million dollars.

The department has made significant contributions and its top ongoing research programs include: 

  • The molecular mechanisms of vestibular schwannoma formation;
  • Virtual modeling of the temporal bone dissection; and
  • Intensification regimens for advanced-stage squamous cell carcinoma.

New grants in the department were recently awarded to Greg Wiet, MD and Brad Welling, MD. Wiet’s work, with collaborator Don Stredney, is highlighted in the article on the “Multi-center Testing of the Virtual Temporal Bone Dissector Simulator." The potential for education of all otolaryngology residents and for preoperative simulation with this technology is encouraging. Deciphering the underlying molecular causes of vestibular schwannomas in our laboratory has moved forward this year as well through the collaboration of Long-Sheng Chang, PhD and a host of dedicated research colleagues. Dr. James Lang, PhD has secured funding to investigate Head and Neck Squamous Cell Carcinomas.

Gregory Wiet, MD, Residency Program Director for Children's Hospital
Associate Professor and Director
Division of Pediatric Otolaryngology
Department of Otolaryngology
Ohio State University Medical Center College of Medicine
Phone: (614) 722-6600
FAX: (614) 722-6609
e-mail

James Lang, PhD
Associate Professor, Otolaryngology
1248 James Cancer Clinic
300 West 10th Avenue
Columbus, OH  43210
Phone: (614) 293-3238
e-mail

Long-Sheng Chang, PhD
Associate Professor, Pediatric Otolaryngology and Molecular & Cellular Biochemistry
Children's Hospital
700 Childrens Drive
Columbus, OH 43205
Phone: (614) 722-2804
e-mail



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The Ohio State University | College of Medicine
Department of Otolaryngology - Head & Neck Surgery
Eye and Ear Institute | 915 Olentangy River Road | Suite 4000 | Columbus, OH 43212
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