Dr. Abraham Jacob was awarded the Mentored Clinical Scientist Research Career Development Award (K08) effective 8/1/2009 – 8/1/2014. The project title is “Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma.” Vestibular schwannomas (VS), brain tumors arising from the balance nerve, are one of the few deadly diseases of the ear, and patients with VS are currently treated with high risk modalities such as surgery and/or radiation therapy because no effective drugs are available. Our proposal seeks to study OSU-03012, a new drug that may revolutionize the treatment of VS. We plan to better understand how OSU-03012 inhibits VS tumor growth and profile its safety/efficacy parameters in order to transition this drug into human clinical trials.
As part of the grant, he will be matriculating in the Masters of Medical Science program at OSU. The Grant Number is 1K08DC009644-01A1 and total direct costs are $1,161,160.
Congratulations to Dr. Jacob!
