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Research Grants

Lauren Bakaletz, PhD
Previous grants of Dr. Bakaletz's


"Antimicrobial Peptides & Innate Immunity in Otits Media"
The goal of this project is investigate the role of innate immunity in otitis media and identify methods to augment these defense mechanisms in order to develop a novel approach for the treatment and/or prevention of otitis media.

PI: Lauren Bakaletz, PhD
NIH R01 | R01DC05847

"Determinants of H. influenzae Virulence in Otitis Media"
The goal of this project is to continue to enhance our understanding of nontypeable Haemophilus influenzae pathogenesis in otitis media as well as continue to identify and characterize putative virulence determinants and assess their potential as vaccine or therapeutic targets.

PI: Lauren O. Bakaletz, PhD
9/30/99 – 11/30/14
NIH R01 | R01DC003915            

"Novel immunotherapeutics for the management of otitis media due to H. influenzae"
The primary goal of this funded initiative is to begin to define the molecular mechanisms that underlie highly promising preliminary data which show that targeting a bacterial protein that stabilizes extracellular DNA (eDNA) present within a biofilm structure is highly effective for reducing or eradicating that structure both in vitro and in vivo then apply this enhanced understanding to the design and testing of novel methods to both treat and prevent infections of the respiratory tract due to NTHI.

PI: Lauren O. Bakaletz, PhD
7/20/11 – 6/30/16                   
NIH R01 | DC011818

"Impact of phasevarions of nontypeable Haemophilus influenzae on otitis media pathobiology and vaccine development"
The primary goal of this project is to further understand the phasevarion of nontypeable H. influenzae -  a mechanism used by this group of microorganisms to rapidly respond to changing microenvironmental cues, thus assuring their ability to either mediate a long-term commensal relationship with their human host or survive under conditions of disease induction.  This improved understanding is expected to have a significant impact on the rational design of vaccine candidates intended to prevent multiple infections of the respiratory tract.

PI: Lauren O. Bakaletz, PhD
01/01/12 – 12/31/14
Australian Government National Health and Medical Research Council

"Development of a transcutaneous immunization patch and assessment of the efficacy afforded against experimental otitis media due to nontypeable Haemophilus influenzae"

PI: Lauren O. Bakaletz, PhD           
8/17/12 – 8/16/13
Center for Clinical & Translational Science, OSU